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Aperiodic Neural Activity is a Better Predictor of Schizophrenia than Neural Oscillations

July 10, 2023
EEG signals consist of both periodic and aperiodic activity, characterized by the (1/fX) shape in the power spectrum but the utility of this activity has not been examined in a task between schizophrenia patients and healthy control participants. We discovered that the steepness of the power spectrum better-predicted group status...

Striatal dopamine in anhedonia: A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation

July 10, 2023
This study used to simultaneous PET-MR to detect reduced striatal dopamine functioning during reward processing and blunted mesocorticolimbic network functional connectivity in a transdiagnostic sample with clinically significant anhedonia.  

Handbook of Self-Compassion

June 6, 2023
This handbook examines contemporary issues in self-compassion science and practice. It describes advances in the conceptualization and measurement of self-compassion as well as current evidence from cross-sectional and experimental research. The volume addresses the foundational issues of self-compassion, including its relationship to self-esteem and mindfulness. In addition, it considers the...

Day-to-day individual alpha frequency variability measured by a mobile EEG device relates to anxiety

June 6, 2023
Investigators used an at-home EEG recording device to monitor the changes in individual alpha frequency (IAF), a unique brain activity signature in the 8-12 Hz frequency band. IAF day-to-day variability was found to be stable over a 1 month period and was also found to be related to trait anxiety.

Balancing the Roles of Clinicians and Police in Separating Firearms from People in a Dangerous Mental Health Crisis: Legal Rules, Policy Tools, and Ethical Considerations

June 6, 2023
As our country aims to implement measures to decrease suicide, of which over half are due to firearms, we explore the role of ERPO (Extreme Risk Protection Order) laws to temporarily remove guns from individuals at elevated risk.

Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices

June 6, 2023
We have discovered distinct roles for the primary (A1) and secondary (A2) auditory cortices in the extraction of complex sound features: specifically, frequency modulation is extracted by A1, while A2 encodes the concurrent multifrequency spectrum.

All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis

June 6, 2023
In this perspective we discuss pre-clinical models of opioid use disorder and argue that we need to consider multiple models to fully understand the human condition.

Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice

June 6, 2023
In this paper we investigated sleep behavior, and patterns in mouse models of opioid use disorder. We investigated sleep behavior also following a sleep deprivation experiment in the same mice after a week of forced abstinence.

Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study.

June 6, 2023
The effects of trauma (childhood sexual abuse) on rate of cognitive decline. The results indicate that epigenetic age acceleration has the potential to serve as a biomarker for cognitive decline in patients with a child maltreatment history or psychiatric disorders

Software to manage regulatory workflows for medical device development at academic medical centers: A critical gap

May 2, 2023
Research from academic institutions is a significant driving force in developing new medical devices. In 2020, the Association of University Technology Managers (AUTM) reported 27,112 invention disclosures [1]. Despite these impressive efforts, disclosures do not translate into commercialized products due to numerous barriers, including weak support infrastructure and the lack...