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Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling

February 8, 2023
Goal directed behavior and reward evaluation were found to be linked with distinct neural oscillations. Furthermore, mood symptoms of depression appear to be related to reward-evaluation and motivation symptoms appear to be related to goal-directed behavior.

Closed-loop control of bistable symptom states

February 8, 2023
Response to paper suggesting the precise mechanism for depressive symptom reduction in closed-loop deep brain stimulation could be illuminated by a dynamical systems approach.

Alpha transcranial alternating current stimulation reduces depressive symptoms in people with schizophrenia and auditory hallucinations: a double-blind, randomized pilot clinical trial.

February 8, 2023
A pilot trials investigating the effect of tACS in treating auditory hallucinations in people with schizophrenia.

A phase II single-arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects

February 8, 2023
This is one of the first studies to examine the use of a medication to minimize cognitive changes that may occur during chemotherapy for breast cancer.

Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure

February 8, 2023
Participants (n=2,021) used wrist wearables for 8 weeks after experiencing a traumatic event. Based on accelerometry data, reduced 24-hour activity variance identified individuals with greater pain severity. Changes in several rest-activity measures were associated with changes in pain, sleep, and anxiety over time. Simple thresholds for these biomarkers identified individuals...

Efficacy of Virtual Care for Depressive Disorders: Systematic Review and Meta-analysis

February 8, 2023
In a review of clinical trials done since 2010, we found that in-person treatment for depression is no different from virtual treatment in terms of symptom remission. Virtual treatments included both telehealth with a mental health provider and fully automated internet-based treatments.

Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study

January 11, 2023
Investigators tested whether anxiety sensitivity, a psychological risk factor defined as fear of anxious arousal, early after trauma predicted posttraumatic outcomes in the eight weeks posttrauma. Results showed that among 2,269 participants from the AURORA study, anxiety sensitivity predicted worse posttraumatic symptom trajectories across many different types of symptoms, including...

Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision

January 11, 2023
This paper describes the development and validation of a clinical decision tool designed for use in the emergency department to identify patients who are at high risk of experiencing persistent and severe post-traumatic stress symptoms three to six months after their initial trauma. The 8-question tool is brief enough for...

Caregiver Experiences of Adolescent School Reentry After Adolescent Hospitalization Due to Suicidal Thoughts and Behaviors: Recommendations to Improve Reentry Practices

January 11, 2023
This study presents caregiver-informed recommendations to facilitate an improved school reentry process for adolescents reintegrating into school after a hospital stay for suicidal thoughts and behaviors. As few reentry recommendations account for the specific challenges faced by families, recommendations informed by caregiver experiences are needed to ensure that families can...

Effect of methylphenidate on functional controllability: a preliminary study in medication-naïve children with ADHD

January 11, 2023
In children with ADHD, methylphenidate may stabilize functional network dynamics and reduce reactivity of brain organization. This, in turn, may make it easier for children with ADHD to achieve brain states necessary for cognitively demanding tasks.