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UNC School of Medicine

Category: Research Publications

Gender Composition in Biomedical Research Grant Submissions and Grant Review Panels Before Versus During the COVID-19 Pandemic

March 8, 2023
This study looked at the proportion of men and women applicants and grant reviewers before and during the pandemic collected from the Health Research Alliance (HRA), which funds biomedical research and training. The gender composition of grant applicants and grant review panels remained similar, except for the review panel composition...

Perimenopausal Effects of Estradiol on Anhedonia and Psychosis Study (PEEPs): study protocol for a neural and molecular mechanistic clinical trial

March 8, 2023
This publication provides an overview of a new clinical trial examining the effects of hormone replacement therapy on perimenopausal mood symptoms and brain indices of dopamine signaling.

Effect of tACS on prefrontal neural activity is menstrual phase dependent in patients with premenstrual dysphoric disorder

February 8, 2023
A case series providing evidence that the impact of tACS is dependent on context of affective and brain state.

Mental Activity as the Bridge Between Neural Biomarkers and Symptoms of Psychiatric Illness

February 8, 2023
We propose that the best chance to discover biomarkers and treatment targets for psychiatric illness is to investigate the relationship between a specific symptom, the correlated mental activity, and the correlated neural activity signature.

Reward-Based Decision-Making Engages Distinct Modes of Cross-Frequency Coupling

February 8, 2023
Goal directed behavior and reward evaluation were found to be linked with distinct neural oscillations. Furthermore, mood symptoms of depression appear to be related to reward-evaluation and motivation symptoms appear to be related to goal-directed behavior.

Closed-loop control of bistable symptom states

February 8, 2023
Response to paper suggesting the precise mechanism for depressive symptom reduction in closed-loop deep brain stimulation could be illuminated by a dynamical systems approach.

Alpha transcranial alternating current stimulation reduces depressive symptoms in people with schizophrenia and auditory hallucinations: a double-blind, randomized pilot clinical trial.

February 8, 2023
A pilot trials investigating the effect of tACS in treating auditory hallucinations in people with schizophrenia.

A phase II single-arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects

February 8, 2023
This is one of the first studies to examine the use of a medication to minimize cognitive changes that may occur during chemotherapy for breast cancer.

Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure

February 8, 2023
Participants (n=2,021) used wrist wearables for 8 weeks after experiencing a traumatic event. Based on accelerometry data, reduced 24-hour activity variance identified individuals with greater pain severity. Changes in several rest-activity measures were associated with changes in pain, sleep, and anxiety over time. Simple thresholds for these biomarkers identified individuals...

Efficacy of Virtual Care for Depressive Disorders: Systematic Review and Meta-analysis

February 8, 2023
In a review of clinical trials done since 2010, we found that in-person treatment for depression is no different from virtual treatment in terms of symptom remission. Virtual treatments included both telehealth with a mental health provider and fully automated internet-based treatments.