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Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats

May 6, 2022
This study shows that repeated activation of the neuroimmune system can drive escalations in alcohol drinking in rats.

The impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

May 6, 2022
Binge drinking is a common pattern of alcohol drinking during adolescence. Using rats, we determined that binge levels of alcohol in adolescence persistently altered perineuronal nets, extracellular structures in the brain, in brain regions important for decision making. This paper adds to a growing body of knowledge around how adolescent...

Pathological Dissociation in the National Comorbidity Survey Replication (NCS-R): Prevalence, Morbidity, Comorbidity, and Childhood Maltreatment

May 6, 2022
The study examines the national prevalence of pathological dissociation in a nationally representative sample (N= 6,644) of the U.S. population.

Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance

May 6, 2022
We identified B-cell specific transcriptional changes in women with PPD compared to controls. These changes are partially mediated by genetic variation.

Exploring Mental Health and Academic Outcomes of Children Receiving Non-manualized, Transdiagnostic, Task-Shifted Mental Health Care From Their Teachers in a Low-and-Middle Income Country

May 6, 2022
In this study, children’s mental health symptoms improved after receiving mental health care from their teachers. We also see evidence to support that academic outcomes, specifically math achievement, may have improved for children after they received task-shifted care from their teachers.

Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

April 5, 2022
This study examined the relationship between neurocognitive performance after a car accident and the development of adverse post-traumatic neuropsychiatric sequelae (APNS) within 8 weeks. Poorer processing speed and poorer short-term memory were found to be associated with the development of some APNS. These results suggest that processing speed and short-term...

Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in post-trauma depression and anxiety following a recent trauma

April 5, 2022
The richness of the AURORA study offered an opportunity to understand why racial/ethnic groups show differences in the prevalence of trauma-related disorders. We observed that Black participants show reduced depression and anxiety symptoms after trauma, despite greater burden of structural inequities, suggestive of psychological resilience to trauma. However, White participants...

Strategies Utilized to Prevent and Control SARS-CoV-2 Transmission in Two Congregate, Psychiatric Healthcare Settings During the Pandemic

March 9, 2022
The COVID-19 pandemic has had a substantial effect on the delivery of psychiatric healthcare. Inpatient psychiatric healthcare facilities have experienced outbreaks of COVID-19, making these areas particularly vulnerable.

Genetic Influences on Longitudinal Trajectories of Cortical Thickness and Surface Area during the First 2 Years of Life

March 9, 2022
Cortical morphology is altered in many psychiatric illness, though little is known about how cortical morphology is develops in early childhood and what factors contribute to it. In this twin study, we found that genetic factors play an important role early childhood development of the cortex.

Scaling Up Patient-Centered Psychological Treatments for Perinatal Depression in the Wake of a Global Pandemic

March 9, 2022
There is a great need to improve access to mental health care for perinatal women. This includes task-sharing among mental health non-specialists, an emphasis on culturally sensitive care, web-based delivery of psychotherapy with some caveats, and a lifespan approach to perinatal mental health. Innovative research efforts are seeking to validate...