Research Publications Archives | Page 29 of 33 | Department of Psychiatry

The University of North Carolina at Chapel Hill

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Translaminar recurrence from layer 5 suppresses superficial cortical layers

The cerebral cortex is full of recurrent connectivities, and their disturbance leads to diseases such as epilepsy and schizophrenia. We found in the auditory cortex that layer 5 to layer 2/3 interlaminar recurrence provides inhibitory feedback, which may stabilize the neural activity and help appropriate information processing in the cortical...

Infant Visual Brain Development and Inherited Genetic Liability in Autism

For the first time, scientists have found that brain differences in the visual brain systems of infants who later are diagnosed with autism are associated with inherited genetic factors.

Prevalence and clinical correlates of cognitive impairment in adults with plasma cell disorders

This is one of the first studies to describe cognitive impairment in patients with multiple myeloma and other plasma cell disorders. We found that cancer-related factors and other medical conditions were associated with objectively tested cognitive impairment and psychosocial and functional factors were associated with patient-reported cognitive impairment.

Methods for characterizing ovarian and adrenal hormone variability and mood relationships in peripubertal females.

Results from the present study (funded by the Foundation of Hope for Research and Treatment of Mental Illness) demonstrated that a substantial proportion of peripubertal females (ages 11-14, within 1 year post-menarche) showed weekly mood changes tied to estrone (57%) and testosterone (37%) flux. This is an important first step...

Increased alcohol self-administration following repeated Toll-like receptor 3 agonist treatment in male and female rats

This study shows that repeated activation of the neuroimmune system can drive escalations in alcohol drinking in rats.

The impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

Binge drinking is a common pattern of alcohol drinking during adolescence. Using rats, we determined that binge levels of alcohol in adolescence persistently altered perineuronal nets, extracellular structures in the brain, in brain regions important for decision making. This paper adds to a growing body of knowledge around how adolescent...

Pathological Dissociation in the National Comorbidity Survey Replication (NCS-R): Prevalence, Morbidity, Comorbidity, and Childhood Maltreatment

The study examines the national prevalence of pathological dissociation in a nationally representative sample (N= 6,644) of the U.S. population.

Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance

We identified B-cell specific transcriptional changes in women with PPD compared to controls. These changes are partially mediated by genetic variation.

Exploring Mental Health and Academic Outcomes of Children Receiving Non-manualized, Transdiagnostic, Task-Shifted Mental Health Care From Their Teachers in a Low-and-Middle Income Country

In this study, children’s mental health symptoms improved after receiving mental health care from their teachers. We also see evidence to support that academic outcomes, specifically math achievement, may have improved for children after they received task-shifted care from their teachers.

Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study

This study examined the relationship between neurocognitive performance after a car accident and the development of adverse post-traumatic neuropsychiatric sequelae (APNS) within 8 weeks. Poorer processing speed and poorer short-term memory were found to be associated with the development of some APNS. These results suggest that processing speed and short-term...