Category: Research Publications

This study shows evidence that temporally resolved and functionally contextualized structural basis sets can accurately reflect dynamic functional processes and capture diagnostically relevant structure-functional coupling while detecting nuanced functionally driven structural components that cannot be captured with traditionally computed structural bases. Differential analysis of component stability across repeated scans from...

This study suggest that reduced pyramidal cell excitability is present at baseline in future CHR-Converters, supporting the hypothesis that hypofunction of pyramidal cells is a primary pathology in schizophrenia, rather than a consequence of chronic illness. Positive symptoms among CHR-Converters may reflect compensatory downregulation of inhibition.

This study reveals small but consistent associations between negative symptom dimensions and predominantly prefrontal region cortical thickness, and limbic region volumes. These findings advance our understanding of the network of anatomical regions that may contribute to the severity of negative symptoms in schizophrenia.

Children as young as 5 years old may experience thoughts about suicide, but these behaviors are not well understood. This study involved 98 children 5 to 10 years of age, recruited for potential adversity exposure, and their caregivers, who answered questions about suicidal thoughts and behaviors (STBs) during an in-home...

Black caregivers of children with autism often face a lack of understanding and acceptance within their communities, leading to emotional strain and family tensions around diagnoses and support. This study, based on interviews with 23 caregivers, highlights both the challenges of denial and misinformation as well as the presence of...

In this paper we identified an undescribed channel (GluD1) in the bed nucleus of the stria terminalis (BNST) that leads to cell depolarization and alters the function of excitatory transmission. The BNST is an area of the brain involved in stress and anxiety which suggests that changes in this channel’s...

This study extends existing knowledge regarding cultural adaptations for suicide prevention interventions among Black youth, suggesting the need for deep-structure adaptations that focus on building trust, fostering transparent communication, and surrounding the youth with a supportive community that values their input and decision-making.

Polygenic scores for depression derived from genome-wide association studies (DEP-PGS) have been previously linked to individual-level stress exposure in youth, but it remains unclear if DEP-PGSs are also associated with neighborhood-level adversity in preadolescent youth. Findings indicated that youth with greater DEP-PGSs were more likely to live in neighborhoods marked...

Our understanding of emotions can be affected by traumatic experiences, but people respond in different ways. This study looked at whether the type of trauma, specifically whether it involved another person (like an assault) or not (like a car accident), helps explain these differences. We followed over 2,200 trauma survivors...

Knowledge of sex differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions. Therefore, the aim of this study was to examine if women and men differ in their vulnerability to risk factors for PTSD. Our findings indicate mechanisms to which men...