Category: Research Publications

Xylazine, an adulterant increasingly found in the illicit opioid drug supply, enhances the interoceptive (subjective) effects of lower doses of fentanyl in rats. These results in rats align with reports from people who use drugs and may be used to better understand the mechanism of the effects of xylazine on...

Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

Our newest paper suggests frontoparietal theta synchrony as a promising therapeutic target for attention disorders. We show that top-down theta connectivity stabilizes attentional performance in a freely moving behavioral task under high cognitive demand.

This new study, using data from over 2,500 participants in the AURORA, sheds light on how adverse posttraumatic neuropsychiatric sequelae (APNS) develop and change during the first two months following trauma through latent transition modeling. In this study, APNS symptoms include pain, depressive symptoms, sleep discontinuity, nightmares, somatic symptoms, concentration/thinking/fatigue,...

The North Carolina Healthy Active Living (NC HeAL) program is an innovative clinical service offered to all Coordinated Specialty Care (CSC) clients in this state. It offers personalized health and wellness coaching to help clients achieve meaningful health improvements. This paper provides a detailed description of the program’s development, the...

We present a physics-informed deep learning framework that models tau pathology propagation in Alzheimer’s disease as an optimal mass transport (OMT) problem constrained by brain geometry, enabling interpretable and accurate prediction of future PET-based pathology distribution. By learning population-level flow dynamics and forecasting subject-specific spreading trajectories, our approach offers a...

Connectivity between the networks in the brain responsible for processing visual input and coordinating response to stimuli may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of...

Connection Learning Healthcare System, one of the eight hubs of the National Institute of Mental Health funded Early Psychosis Intervention Network, supports uniform data collection, analysis, feedback and infrastructure development to promote a culture of continuous quality improvement across 25 Coordinated Specialty Care programs serving young people experiencing first episode...

Fluctuations in sex hormones may impact risk for PTSD, as estradiol has been shown to influence PTSD severity and biomarkers of PTSD. Using the AURORA data, we were able to examine how estradiol levels at the time of the trauma were associated with changes in autonomic function and fear learning...

Post-traumatic stress (PTS) symptoms and substance use behaviors commonly co-occur after a traumatic event. However, whether individual-, household-, or neigborhood-level factors impact this relationship is understudied due to lack of data on long-term outcomes and geographic variability in samples. From the Advancing Understanding of RecOvery afteR traumA (AURORA) study, we...