This program was established to better understand the causes, course and treatment of “Clinical High Risk Symptoms”. These symptoms include changes in thinking, mood and perception.

PRIME Logo 2015
People experiencing the following symptoms may be at increased risk for developing an illness like psychosis:

  • Confusion about what is real or imaginary.
  • Frequent déjà vu.
  • Wondering if people can read minds, hear thoughts.
  • Mystical/philosophical/religious ideas.
  • The familiar feels strange, confusing, threatening, or has special meaning.
  • It seems that the mind/eyes/ears are playing tricks or are misperceiving reality (for example mistaking a dog barking for someone calling out a name).
  • Changes in perceptual sensitivity–heightened or dulled.
  • Unexpected perceptual changes, noises, lights, shadows, geometrical designs, and whispers or hearing one’s name called.
  • Increased sensitivity to smells and tastes.
  • Notions of being watched, singled out, talked about, or plotted against, even if unsure whether it is true.
  • Confused or muddled thinking.
  • Using the wrong words, talking about things irrelevant to context of conversations, or going off track.
  • Difficulty paying attention or remembering simple things.
  • Notions of being especially important, talented, gifted, powerful, or superior to others.
  • Decreased interest in spending time or talking with friends or family.
  • Less interested in everyday activities or hobbies.
  • Prefer to be alone.

Current PRIME Study: NAPLS III

The UNC Department of Psychiatry is conducting a research study to find out more about mental illness. If you have had any of the above symptoms in the past few months, are between 12-30 years old, and have not been diagnosed with psychosis, you may be eligible to participate in a study in the PRIME Research Program.

You may be eligible to receive free study related medical evaluations and monetary compensation. Study participation includes multiple visits lasting 2-8 hours over 2 years. These visits will take place at the University of North Carolina at Chapel Hill.

To see if you may be eligible to participate, please complete the ‘Simple Survey’ at the top right of the page or call (877) PRIME-19 or (877) 774-6319.

The Project is funded by the National Institute of Mental Health
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Committee on the Protection of the Rights of Human Subjects
The BioMedical IRB
University of North Carolina