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Following trauma, individuals often face significant neuropsychiatric challenges, known as adverse post-traumatic neuropsychiatric sequelae (APNS). Although the biological factors behind APNS remain unclear, this study explored the role of the microbiota-gut-brain axis in understanding and influencing components of APNS. By analyzing stool samples from trauma-exposed emergency department patients, we identified...

Fifty-nine adolescents (Mage = 15.81, 70% female) with subsyndromal depressive symptomswere randomized to group-based Mindful Self-Compassion for Teens (N = 30) or a newly developed active control Healthy Lifestyles group (N = 29). Results indicated that the risk of developing clinically significant depression was 2.6 times higher in the control...

Among 272 older breast cancer survivors, 15% experienced high depressive symptom trajectories over a 3-year period after diagnosis. Baseline anxiety, frailty, and lower social support were associated with worse outcomes.