Skip to main content


My research focus is on peripheral vascular disease, specifically chronic limb-threatening ischemia (CLTI). This is a very clinically challenging and resource-intensive population to manage and there are ever-changing therapeutic options that make CLTI fascinating to treat and research. With an MPH, I have significant expertise in large database research and surgical outcomes research. I am the site- PI for a national randomized controlled trial comparing endovascular versus open revascularization in CLI patients (BEST-CLI) and involved in two other wound clinical trials currently.
Additionally, I have had a long-standing special interest in healthcare delivery to marginalized patient populations and have published work on disparities in the treatment of CLTI and limb loss. I also work on clinical and research projects related to minimizing care variation to improve surgical outcomes and address healthcare disparities.

 

Enhanced Recovery After Surgery

 

Precision Health

 

Disparities

 

Surgical Outcomes

 

Grants

  • Analysis of a Machine Learning–Based Risk Stratification Scheme for Chronic Limb-Threatening Ischemia, NIH R21, National Heart, Lung, and Blood Institute, Principal Investigator, (2023-2025).
  • Developing a Flexible Statistical Framework to Accelerate Data-Driven Treatment Algorithms for Peripheral Artery Disease (PAD), Foundation to Advance Vascular Cures, Inaugural Binkley Award Recipient (2024-2025).

  • Determining the best personalized treatment sequence for patients with severe peripheral artery disease at high risk for limb loss. Submitted to National Institutes of Health, National Principal Investigator, 21-site Sequential Multiple Assessment Randomized Trial (Pending)
  • Tailored Treatment Strategies for Patients with Chronic Limb Threatening Ischemia submitted to the National Institutes of Health (Pending)
  • Impact of treatment sequences on disease-free survival: A secondary analysis of the BEST-CLI trial, Submitted to the National Institutes of Health (Pending)
  • BEST-CLI Imaging Core, Novo Nordisk Foundation (Active)
  • Using Precision Medicine to Define Adaptive Treatment Strategies for Patients with Chronic Limb-Threatening Ischemia, Society for Vascular Surgery Foundation Clinical Research Seed Grant (Completed)
  • Using Precision Medicine to Define Adaptive Treatment Strategies for Patients with Chronic Limb-Threatening Ischemia, The North Carolina Translational and Clinical Sciences Institute Pilot Grant, 2020- 2021, Principal Investigator (Completed)
  • Staging Peripheral Arterial Disease, UNC Center for Healthcare Innovation, 2018-2019, Principal Investigator (Completed)

 


Email Us 
katharine_mcginigle@med.unc.edu

 

Call Us
(919) 966-3392 (Office Phone)
(919) 966-2898 (Fax)