Research

McGinigle Lab Meet Our Team Research

My research focus is on peripheral vascular disease, specifically chronic limb-threatening ischemia (CLTI). This is a very clinically challenging and resource-intensive population to manage and there are ever-changing therapeutic options that make CLTI fascinating to treat and research. With an MPH, I have significant expertise in large database research and surgical outcomes research. I am the site- PI for a national randomized controlled trial comparing endovascular versus open revascularization in CLI patients (BEST-CLI) and involved in two other wound clinical trials currently.

Additionally, I have had a long-standing special interest in healthcare delivery to marginalized patient populations and have published work on disparities in the treatment of CLTI and limb loss. I also work on clinical and research projects related to minimizing care variation to improve surgical outcomes and address healthcare disparities.

Enhanced Recovery After Surgery

• A Framework for Perioperative Care for Lower Extremity Vascular Bypasses: A Consensus Statement by the Enhanced Recovery after Surgery (ERAS®) Society and Society for Vascular Surgery

  McGinigle KL, Spangler EL, Ayyash K, Arya S, Settembrini AM, Thomas MM, Dell KE, Swiderski IJ, Davies MG, Setacci C, Urman RD, Howell SJ, Garg J, Ljungvist O, de Boer HD.J Vasc Surg. 2023 May;77(5):1295-1315. doi: 10.1016/j.jvs.2023.01.018. Epub 2023 Mar 16.PMID: 36931611 Review.
  

• Perioperative Care in Open Aortic Vascular Surgery: A Consensus Statement by the Enhanced Recovery after Surgery (ERAS®) Society and Society for Vascular Surgery

  McGinigle KL, Spangler EL, Pichel AC, et al. J Vasc Surg 2022 Feb 15: S0741-5214(22)00249-X. doi: 0.1016/j.jvs.2022.01.131. Online ahead of print. PMID: 35181517

• The Use of Sequential Surveys to Shorten Implementation Time for Healthcare System-Level Enhanced Recovery After Surgery (ERAS) Pathways

  Adams UC, Moulthrop AJ, Malay B, Straube LE, McNaull PP, McGinigle KL, Phillips MR.Am Surg. 2023 Feb 14:31348231156765. doi: 10.1177/00031348231156765. Online ahead of print.PMID: 36786426 Free article.

Precision Health

• The Use of Sequential Surveys to Shorten Implementation Time for Healthcare System-Level Enhanced Recovery After Surgery (ERAS) Pathways.Analysis of a Machine Learning-Based Risk Stratification Scheme for Chronic Limb-Threatening Ischemia

  Chung J, Freeman NLB, Kosorok MR, Marston WA, Conte MS, McGinigle KL. JAMA Netw Open. 2022 Mar 1; 5(3):e223424. doi: 10.1001/jamanetworkopen.2022.3424. PMID: 35315918

• Precision Medicine Enables More TNM-Like Staging in Patients With Chronic Limb Threatening Ischemia

  McGinigle KL, Freeman NLB, Marston WA, Farber A, Conte MS, Kosorok MR, Kalbaugh CA. Front Cardiovasc Med. Front Cardiovasc Med. 2021 Jul 16; 8:709904. doi: 10.3389/fcvm.2021.709904. eCollection 2021. PMID: 34336963

• Balancing Evidence-Based Care with Patient-Centered Individualized Care

  Freeman NLB, Browder SE, McGinigle KL. J Vasc Surg Venous Lymphat Disord. 2023 Sep 7:S2213-333X(23)00315-3. doi: 10.1016/j.jvsv.2023.08.005. Online ahead of print. PMID: 37689363

Disparities

• Differential Impact of Missed Initial Wound Clinic Visit on 6-month Wound Healing by Race/Ethnicity Among Patients with Chronic Limb-Threatening Ischemia

  Browder SE, Yohann A, Filipowicz TR, Freeman NLB, Marston WA, Heisler S, Farber MA, Patel SR, Wood JC, McGinigle KL.Wound Repair Regen. 2023 Sep-Oct;31(5):647-654. doi: 10.1111/wrr.13116. Epub 2023 Aug 10.PMID: 37534781

• Sex Related Disparities in Intervention Rates and Type of Intervention in Patients with Aortic and Peripheral Arterial Diseases in the National Inpatient Sample Database. 

  McGinigle KL, Browder SE, Shalhub S, Harris L, Minc S. J Vasc Surg. 2020 Dec 7: S0741-5214(20)32506-4. doi: 10.1016/j.jvs.2020.11.034. Epub 2020 Dec 8. PMID: 33301865

• Investigating the Impact of Suboptimal Prescription of Preoperative Antiplatelets and Statins on Race and Ethnicity-Related Disparities in Major Limb Amputation.

  Kalbaugh CA, Witrick B, Howard KA, Sivaraj LB, McGinigle KL, Robinson WP 3rd, Cykert S, Hicks CW, Lesko CR.Vasc Med. 2023 Sep 22:1358863X231196139. doi: 10.1177/1358863X231196139. Online ahead of print.PMID: 37737127

Surgical Outcomes

• Analysis of Wound Healing Time and Wound-Free Period in Patients with Chronic Limb-Threatening Ischemia Treated With and Without Revascularization

  Browder SE, Ngeve SM, Hamrick ME, Wood JE, Parodi FE, Pascarella LE, Farber MA, Marston WA, McGinigle KL J Vasc Surg. 2022 Dec;76(6):1667-1673.e1. doi: 10.1016/j.jvs.2022.05.025. Epub 2022 Jul 8. PMID: 35810955.

• Poor Glycemic Control is Associated With Significant Increase in Major Limb Amputation and Adverse Events in the 30-day Postoperative Period After Infrainguinal Bypass

  McGinigle KL, Kindell DG, Strassle PD, Crowner JR, Pascarella L, Farber MA, Marston WA, Arya S, Kalbaugh CA. J Vasc Surg. 2020 Mar 2: S0741-5214(19)32893-9. doi: 10.1016/j.jvs.2019.11.048. Epub 2020 Mar 2. PMID: 32139308.

• Surgical Site Infection After Open Lower Extremity Revascularization Associated With Doubled Rate of Major Limb Amputation

  Pherson MJ, Strassle PD, Aucoin VJ, Kalbaugh CA, McGinigle KL. J Vasc Surg. 2022 Oct;76(4):1014-1020. doi: 10.1016/j.jvs.2022.04.040. Epub 2022 Jun 11. PMID: 35697308; PMCID: PMC9765967.

Grants

• Determining the best personalized treatment sequence for patients with severe peripheral artery disease at high risk for limb loss. Submitted to National Institutes of Health, National Principal Investigator, 21-site Sequential Multiple Assessment Randomized Trial (Pending)

• Tailored Treatment Strategies for Patients with Chronic Limb Threatening Ischemia submitted to the National Institutes of Health (Pending)

• Impact of treatment sequences on disease-free survival: A secondary analysis of the BEST-CLI trial, Submitted to the National Institutes of Health (Pending

• BEST-CLI Imaging Core, Novo Nordisk Foundation (Active)

• Using Precision Medicine to Define Adaptive Treatment Strategies for Patients with Chronic Limb-Threatening Ischemia, Society for Vascular Surgery Foundation Clinical Research Seed Grant (Completed)

• Using Precision Medicine to Define Adaptive Treatment Strategies for Patients with Chronic Limb-Threatening Ischemia, The North Carolina Translational and Clinical Sciences Institute Pilot Grant, 2020- 2021, Principal Investigator (Completed)

• Staging Peripheral Arterial Disease, UNC Center for Healthcare Innovation, 2018-2019, Principal Investigator (Completed)

Email Us  katharine_mcginigle@med.unc.edu   Call Us (919) 966-3392 (Office Phone) (919) 966-2898 (Fax)