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UNC Blood Research Center

Publications

  1. Sharma S, Antoniak S. New insights in the pathology of chronic thromboembolic pulmonary hypertension. JACC Basic Transl Sci. 2024 JACC Basic Transl Sci. 2024 Jan 22;9(1):117-119. doi: 10.1016/j.jacbts.2023.11.009.
  2. Sharma S, Antoniak S. Hemostasis in arenavirus infection.Blood 2023 Dec 14;142(24):2042-2043.
  3. Zhang Y, Bharathi V, Dokoshi T, de Anda J, Ursery LT, Kulkarni NN, Chen J, Luo EWC, Wang L4, Xu H, Coady A, Zurich R, Lee MW, Matsui T, Lee H, Chan LC, Schepmoes AA, Lipton MS, Zhao R, Adkins JN, Clair GC, Thurlow LR, Schisler JC, Wolfgang MC, Hagan RS, Yeaman MR, Weiss TM, Chen X, Li MMH, Nizet V, Antoniak S, Mackman N, Gallo RL, Wong GCL. Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2300644120. doi: 10.1073/pnas.2300644120.
  4. Sharma S, Ursery LT, Bharathi V, Miles SD, Williams WA, Elzawam AZ, Schmedes CM, Egnatz GJ, Fernandez JA, Palumbo JS, Griffin JH, Mackman N, Antoniak S. APC-PAR1-R46 ignaling limits CXCL1 expression during poly IC-indiced airway inflammation in mice. J Thromb Haemost. 2023; 21:3279-3282.
  5. Lee HY, You DJ, Taylor-Just A, Tisch LJ, Bartone RD, Atkins HM, Ralph LM, Antoniak S, Bonner JC. Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes. Part Fibre Toxicol. 2023 Aug 14;20(1):32.
  6. Rudran T, Antoniak S, Flick MJ, Ginsberg MH, Wolberg AS, Bergmeier W, Lee RH. Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography. J Thromb Haemost. 2023 Aug;21(8):2236-2247.
  7. Grover Sp, Bharathi V, Posma J, Griffin JH, Palumbo J, Mackman N, Antoniak S. Thrombin mediated activation of PAR1 enhances doxorubicin induced cardiac injury in mice. Blood Adv. 2023, 7:194-1953.
  8. Sharna S, Tyagi T, Antoniak S. Platelet in thrombo-inflammation: Unraveling new therapeutic targets. Front Immunol. 2022; 13:1039843.
  9. Antoniak S, Phungphong S, Cheng Z, Jensen BC. Novel mechanisms of anthracycline-induced cardiovascular toxicity: A focus on thrombosis, cardiac atrophy, and programmed cell death. Front Cardiovasc Med. 2022; 8:817977.
  10. Negrón O, Hur WS, Prasad J, Paul DS, Rowe SE, Degen JL, Abrahams SR, Antoniak S, Conlon BP, Bergmeier W, Hӧӧk M, Flick MJ. Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. PLoS Pathog. 2022; 18:e1010227.
  11. Gunther RC, Bharathi V, Miles SD, Tumey LR, Schmedes CM, Tatsumi K, Bridges MD, Martinez D, Montgomery SA, Beck MA, Camerer E, Mackman N, Antoniak S. Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice. Front Immunol. 2021; 12:791017.
  12. Kim SJ, Carestia A, McDonald B, Zucoloto AZ, Grosjean H, Davis RP, Turk M, Naumenko V, Antoniak S, Mackman N, Abdul-Cader MS, Abdul-Careem MF, Hollenberg MD, Jenne CN. Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection. Front Immunol. 2021; 12:772859.
  13. Lee RH, Kawano T, Grover SP, Bharathi V, Martinez D, Cowley DO, Mackman N, Bergmeier W, Antoniak S. Genetic deletion of platelet PAR4 results in reduced thrombosis and impaired hemostatic plug stability. J Thromb Haemost. 2022; 20:422-433.
  14. Mackman N, Grover SP, Antoniak S. Tissue factor expression, extracellular vesicles, and thrombosis after infection with the respiratory viruses influenza A virus and coronavirus. J Thromb Haemost. 2021; 19:2652-2658.
  15. Bode MF, Schmedes CM, Egnatz GJ, Bharathi V, Hisada YM, Martinez D, Kawano T, Weithauser A, Rosenfeldt L, Rauch U, Palumbo JS, Antoniak S, Mackman N. Cell type-specific roles of PAR1 in Coxsackievirus B3 infection. Sci Rep. 2021; 11:14264.
  16. Subramaniam S, Ogoti Y, Hernandez I, Zogg M, Botros F, Burns R, DeRousse JT, Dockendorff C, Mackman N, Antoniak S, Fletcher C, Weiler H. A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 2021; 5:2760-2774.
  17. Antoniak S, Mackman N. Platelets and viruses. 2021; 32:325-330.
  18. Antoniak S, Tatsumi K, Schmedes CM, Egnatz GJ, Auriemma AC, Bharathi V, Stokol T, Beck MA, Griffin JH, Palumbo JS, Mackman N. PAR1 regulation of CXCL1 expression and neutrophil recruitment to the lung in mice infected with influenza A virus. J Thromb Haemost. 2021; 19:1103-1111.
  19. Antoniak S, Mackman N. New Cellular source of TF (Tissue Factor)-positive extracellular vesicles in the circulation. Arterioscler Thromb Vasc Biol. 2021; 41:266-268.
  20. Schweickert PG, Yang Y, White EE, Cresswell GM, Elzey BD, Ratliff TL, Arumugam P, Antoniak S, Mackman N, Flick MJ, Konieczny SF. Thrombin-PAR1 signaling in pancreatic cancer promotes immunosuppressive microenviroment. J Thromb Haemost. 2021; 19:161-172.
  21. Mackman N, Antoniak S, Wolberg AS, Kasthuri R, Key NS. Coagulation abnormalities and thrombosis in patients infected with SARS-CoV-2 and other pandemic viruses. Arterioscler Thromb Vasc Biol. 2020; 40:2033-2044.
  22. Grover SP, Schmedes CM, Auriemma AC, Butler E, Parrish ML, Miszta A, Cleuren AC, Visser M, Heitmeier S, Posma JJ, Spronk HM, Antoniak S, Wolberg AS, Pawlinski R, Gailani D, Mackman N. Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor. Blood Adv. 2020; 4:207-216.
  23. Boucher AA, Rosenfeldt L, Mureb D, Shafer J, Sharma BK, Lane A, Crowther RR, McKell MC, Whitt J, Alenghat T, Qualls J, Antoniak S, Mackman N, Flick MJ, Steinbrecher KA, Palumbo JS. Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis. J Thromb Haemost. 2020; 18:91-103.
  24. Tatsumi K, Schmedes CM, Houston ER, Butler E, Mackman N, Antoniak S. Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection. Cell Immunol. 2019; 344:103949.
  25. Posma JJ, Grover SP, Hisada Y, Owens AP 3rd, Antoniak S, Spronk HM, Mackman N. Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases. Atherioscler Thromb Vasc Biol. 2019; 39:13-24.
  26. Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N. Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol. 2018; 122:80-87.
  27. Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H. Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis. Res Pract Thromb Haemost. 2018; 2:407-428.
  28. Antoniak S. The coagulation system in host defense. Res Pract Thromb Haemost. 2018; 2:549-557.
  29. Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S, Mackman N. The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction. Thromb Res. 2018; 167:128-134.
  30. Mackman N, Antoniak S. Tissue factor and oxidative stress. 2018; 131:2094-5.
  31. Antoniak S, Mackman N. Letter to Editor response: Endothelial cell tissue factor and coagulation.Trends Cardiovasc Med. 2017; 27:157.
  32. Antoniak S, Cardenas JC, Buczek LJ, Church FC, Mackman N, Pawlinski R. Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation.  2017; 136:258-268.
  33. Antoniak S, Tatsumi K, Bode M, Vanja S, Williams JC, Mackman N. Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice.J Innate Immun. 2017; 9:181-192.
  34. Tatsumi K, Antoniak S, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM 3rd, Bastarache JA, Mackman N. Anticoagulation increases alveolar hemorrhage in mice infected with influenza A. Physiol Rep. 2016; e13071.
  35. Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor deficiency increases alveolar hemorrhage and death in influenza A infected mice. J Thromb Haemost. 2016; 14:1238-48.
  36. Antoniak S, Mackman N. Tissue factor expression by the endothelium: Coagulation or inflammation? Trends Cardiovasc Med. 2016; 26:304-5.
  37. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 augments compression stress-induced tissue factor expression in human airway epithelial cells. Am J Respir Cell Mol Biol. 2016; 54:524-31.
  38. Rautou PE, Tatsumi K, Antoniak S, Owens AP 3rd, Sparkenbaugh E, Holle LA, Wolberg AS, Kopec AK, Pawlinski R, Luyendyk JP, Mackman N. Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury. J Hepatol. 2015; 64:53-9.
  39. Owens AP 3rd, Edwards TL, Antoniak S, Geddings JE, Jahangir E, Wei WQ, Denny JC, Boulaftali Y, Bergmeier W, Daugherty A, Sampson UK, Mackman N. Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm. Atherioscler Thromb Vasc Biol. 2015; 35:2035-41.
  40. Stavrou EX, Fang C, Merkulova A, Alhalabi O, Grobe N, Antoniak S, Mackman N, Schmaier AH. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1 and KLF4 and decreased tissue factor. 2014; 125:710-9.
  41. Tatsumi K, Antoniak S, Monroe DM 3rd, Khorana AA, Mackman N. Evaluation of a new commercial assay to measure microparticle tissue factor activity in plasma: communication from the SSC of the ISTH. J Thromb Haemost. 2014; 12:1932-4.
  42. Antoniak S, Sparkenbaugh EM, Pawlinski R. Tissue Factor, Protease Activated Receptors and Pathologic Heart Remodeling. Thromb Haemost. 2014; 112:893-900.
  43. Antoniak S and Mackman N. Multiple roles of the coagulation protease cascade during virus infection. 2014; 123:2605-13.
  44. Mackman N and Antoniak S. Roles of PAR-1 and PAR-2 in viral myocarditis. Thromb Res. 2014; 133:S18-20.
  45. Antoniak S and Mackman N. Coagulation, protease-activated receptors, and viral myocarditis. J Cardiovasc Transl Res. 2014; 7:203-11.
  46. Antoniak S, Sparkenbaugh EM, Tencati M, Rojas M, Mackman N, Pawlinski R. Protease activated receptor-2 contributes to heart failure. PLoS One. 2013; 8:e81733.
  47. Weithauser A, Bobbert P, Antoniak S, Böhm A, Rauch BH, Klingel K, SavvatisK, Kroemer HK, Tschope C, Stroux A, Zeichhardt H, Poller W, Mackman N, Schultheiss HP, Rauch U. Protease-activated receptor 2 regulates the innate immune response to viral Infection in a CVB3-induced myocarditis. J Am Coll Cardiol 2013; 62:1737-45.
  48. Antoniak S, Owens AP 3rd, Baunacke M, Williams JC, Lee RD, Weithäuser A, Sheridan PA, Malz R, Luyendyk JP, Esserman DA, Trejo J, Kirchhofer D, Blaxall B, Pawlinski R, Beck MA, Rauch U, Mackman N. PAR-1 contributes to the innate immune response after viral infection. J Clin Invest. 2013; 123:1310-22.
  49. Boltzen U, Eisenreich A, Antoniak S, Weithaeuser A, Fechner H, Poller W, Schultheiss HP, Mackman N, Rauch U. Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis. J Mol Cell Cardiol. 2012; 52:1056-65.
  50. Owens AP 3rd, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012; 122:558-68.
  51. Antoniak S, Pawlinski R, Mackman N. Protease-activated receptors and myocardial infarction. IUBMB Life 2011; 63:383-9.
  52. Antoniak S, Rojas M, Spring D, Bullard TA, Verrier ED, Blaxall BC, Mackman N, Pawlinski R. Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Atherioscler Thromb Vasc Biol. 2010; 30:2136-42.
  53. Pawlinski R, Wang JG, Owens AP 3rd, Williams JC, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N. Hematopoietic and non-hematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. 2010; 16:806-14.
  54. Antoniak S, Boltzen U, Eisenreich A, Stellbaum C, Poller W, Schultheiss HP, Rauch U. Regulation of cardiomyocyte full-length tissue factor expression and microparticle release under inflammatory conditions in vitro. J Thromb Haemost. 2009; 7:871-8.
  55. Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S, Poller W, Schultheiss HP, Rauch U. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Circ Res. 2009; 104:589-99.
  56. Bobbert P, Rauch U, Stratmann B, Goldin-Lang P, Antoniak S, Bobbert T, Schultheiss HP, Tschoepe D. High molecular weight adiponectin correlates positively with myeloperoxidase in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2008; 82:179-84.
  57. Goldin-Lang P, Tran QV, Fichtner I, Eisenreich A, Antoniak S, Schulze K, Coupland SE, Poller W, Schultheiss HP, Rauch U. Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumor metastasis. Oncol Rep. 2008; 20:123-8.
  58. Antoniak S, Boltzen U, Riad A, Kallwellis-Opara A, Rohde M, Dörner A, Tschöpe C, Noutsias M, Pauschinger M, Schultheiss HP, Rauch U. Viral myocarditis and coagulopathy: Increased Tissue Factor expression and plasma thrombogenicity. J Mol Cell Cardiol. 2008; 45:118-26.
  59. Bobbert P, Antoniak S, Schultheiss HP, Rauch U. Globular adiponectin but not full length adiponectin induces increased procoagulability in human endothelial cells. J Mol Cell Cardiol. 2008; 44:388-94.
  60. Goldin-Lang, Pels K, Tran Q-V, Szotowski B, Wittchen F, Antoniak S, Willich T, Witt H, Hummel M, Lenze D, Poller W, Schultheiss HP, Rauch U. Effect of ionizing radiation on cellular procoagulability: transcriptional tissue factor upregulation is associated with inflammation and apoptosis. Haematologica 2007; 92:1091-8.
  61. Goldin-Lang P, Niebergall F, Antoniak S, Szotowski B, Rosenthal P, Pels K, Schultheiss HP, Rauch U. Ionizing radiation induces upregulation of cellular procoagulability and tissue factor expression in human peripheral blood mononuclear cells. Thromb Res. 2007; 120:857-64.
  62. Szotowski B; Antoniak S, Goldin-Lang P, Tran Q-V, Pels K, Rosenthal P, Bogdanov VY, Borchert H-H, Schultheiss HP, Rauch U. Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells. Cardiovasc Res. 2007; 73:806-12.
  63. Rauch U and Antoniak S. Tissue factor-positive microparticles in blood associated with coagulopathy in cancer. Thromb Haemost. 2007; 97:9-10.
  64. Szotowski B, Antoniak S, Rauch U. Alternatively Spliced Tissue Factor. Trends Cardiovasc Med. 2006; 16:177-82.
  65. Szotowski B, Antoniak S, Poller W, Schultheiss HP, Rauch U. Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines. Circ Res. 2005; 96:1233-9.
  66. Rauch U, Antoniak S, Boots M, Schulze K, Goldin-Lang P, Stein H, Schultheiss H-P, Coupland SE. Association of tissue-factor upregulation in squamous-cell carcinoma of the lung with increased tissue factor in circulating blood. Lancet Oncol. 2005; 6;254.
  67. Szotowski B, Goldin-Lang P, Antoniak S, Bogdanov VY, Pathirana D, Pauschinger M, Dörner A, Kuehl U, Coupland SE, Nemerson Y, Hummel M, Poller W, Hetzer R, Schultheiss H-P, Rauch U. Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. J Am Coll Cardiol. 2005; 45:1081-9.