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The UNC Blood Research Center (BRC) was established to promote interdisciplinary research in non-malignant blood disorders across UNC. It will seek to advance the work in the following specific areas.

 

Thrombosis

One in four of the US population will succumb to a terminal thrombotic event, such as: myocardial infarction, stroke, or venous thromboembolism.

Basic science discoveries have paved the way towards better prophylactic and therapeutic approaches to thrombosis. However, a better understanding of the mechanisms underlying thrombosis and prevention without any risk of bleeding remains an unmet need. The BRC seeks to investigate potential approaches to both aims.

Bleeding Disorders

UNC is a world leader in hemophilia, from the development and administration of the first coagulation factor VIII concentrate to the role of the Chapel Hill dog colonies of the Francis Owen Blood Research Center in the pre-clinical testing of protein and gene therapies. The BRC aims to address the broad challenges that remain in numerous other inherited and acquired bleeding disorders.

Sickle Cell Disease

Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent.

Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. We will continue to expand our research efforts to this under-served patient population into the future.


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1 week ago

Erica Sparkenbaugh, PhD will give a talk on January 18, 2022 at 1pm; North American Vascular Biology Organization on-line symposium

Erica Sparkenbaugh, Research Assistant Professor in the Blood Research Center and Division of Hematology will give a talk entitled “The Role of Thrombin and PAR-1 in Microvascular Stasis in Sickle Cell Disease” to the North American Vascular Biology Organization in an Online Symposium on Thrombosis in Vascular Occlusive Disorders. More information: Navbo symposium Register online: …

1 month ago

Steve Woosuk Hur, PhD of the Flick Laboratory is the first author of a manuscript accepted for publication in Blood

Publication News! “Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with a Fga truncation mutation” Woosuk Steve Hur, PhD of the Flick Laboratory is the first author of a manuscript accepted for publication in Blood In this collaborative study involving several UNC BRC labs (Flick, Bergmeier and Wolberg), Hur et al., determined the impact of …