Resources

• Management of Pelvic/Sacral Osteomyelitis in Adults with or without Skin and Soft Tissue Infections

  11/17/25

  Adult/Peds: Adult    

  Keywords: There is growing evidence that prolonged IV antibiotic treatment for osteomyelitis (OM) in the absence of a plan for wound coverage does not provide any benefit and may be associated with some risk (i.e., development of multidrug-resistant organisms). This guideline aims to streamline and optimize evaluation and management of patients with pelvic or sacral osteomyelitis while acknowledging that these are complex patients who require individualized care and for whom this management plan may not be appropriate.

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• Antibiogram: A Clinician’s Guide

  11/13/25

  Adult/Peds: Adult, Pediatric*    

  Keywords:

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• Malaria Diagnosis and Initial Management

  11/02/25

  Adult/Peds: Adult, Pediatric*    

  Keywords: Immediate guidance for the initial diagnosis and management of malaria at UNC Hospitals. Infectious Diseases consultation is recommended when malaria is diagnosed or strongly suspected. key words: malaria, antimalarial, artesunate, dengue, Chikungunya, P. falciparum, P. vivax, P. ovale

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• Gram-negative Bacteremia Treatment Pathway

  10/14/25

  Adult/Peds: Adult  Organism: Bacteria  

  Keywords: This treatment pathway is intended for patients with uncomplicated Gram-negative bacteremia with a known pathogen and pending microbiological susceptibility testing results.

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• Diagnosis and Management of Clostridioides difficile Infection in Adult and Pediatric Patients

  09/22/25

  Adult/Peds: Adult, Pediatric*  Organism: Bacteria  

  Keywords: c. diff, c. difficile, fidaxomicin, bezlotoxumab, vancomycin, Clostridioides difficile, CDI, diarrhea, Clostridium difficile

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• Azole Antifungal Therapeutic Drug Monitoring

  07/25/25

  Adult/Peds: Adult, Pediatric*  Organism: Fungi  

  Keywords: Certain azole antifungal drugs require therapeutic drug monitoring (TDM) due to important exposureresponse relationships and significant pharmacokinetic variability. This guideline outlines recommendations for the TDM of itraconazole, posaconazole, voriconazole, and isavuconazole.

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• UNC Medical Center Antibiogram

  07/11/25

  Adult/Peds: Adult, Pediatric*  Organism: Bacteria  

  Keywords: Antimicrobial susceptibility organisms submitted to the University of North Carolina Hospitals Microbiology Laboratory between 1/1/2024 and 12/31/2024. Antibiograms help guide the clinician and pharmacist in selecting the best empiric antimicrobial treatment in the event of pending microbiology culture and susceptibility results.

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• Vancomycin Dosing Guidelines (Adult)

  05/01/25

  Adult/Peds: Adult    

  Keywords: vancomycin, SDD

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• Isolation Precautions

  03/01/25

  Adult/Peds: Adult, Pediatric*    

  Keywords: isolation, epidemiology, infection, prevention

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• Antibiotic Dosing for Hemodialysis and Altered Kidney Function

  01/24/25

      

  Keywords:

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• Evaluating New Fever in the Pediatric Intensive Care Unit

  09/26/24

  Adult/Peds: Pediatric*    

  Keywords:

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• Pediatric Community-acquired Pneumonia (CAP) and Influenza Guidelines

  08/19/24

  Adult/Peds: Pediatric*    

  Keywords: This document provides guidance in management, including diagnostic evaluation, antimicrobial therapy, procedural management, and disposition, of children with community-acquired pneumonia (CAP). It is not intended to replace clinician judgment in individual cases; however, it should apply to the vast majority of patients diagnosed with CAP.

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