Education and Training

Michigan State University, BS, 2002
University of Michigan, Ann Arbor, PhD, 2009
University of Michigan, Ann Arbor, Postdoctoral, 2009-2011
University of Michigan, Ann Arbor, Research Investigator, 2011-2014

Areas of Interest

My laboratory investigates the regulation and function of disease-linked proteins, with a specific focus on post-translational modifications (PTMs). PTMs involve biochemical reactions that alter the structure, function, interactions, localization, and abundance of cellular proteins. During homeostasis, PTMs, such as phosphorylation and glycosylation, enable cells to respond to stimuli and adapt to changing conditions. In disease states, altered expression or activity of PTM on/off enzymes, leads to aberrant protein regulation. Therefore, understanding PTM mechanisms can yield novel therapeutic targets and markers of disease activity. We pursue translational projects in this space, with an emphasis on two specific areas: (i) Regulation and function of the enzyme CD73 in liver homeostasis, chronic injury, and cancer and (ii) Regulation and function of glial intermediate filaments in pediatric neurodegenerative diseases.

Awards and Honors

Postdoctoral Translational Scholars Program Award, University of Michigan, 2009-2011

NIH K01 Mentored Research Scientist Development Award, 2011-2016

Research Recognition Award – APS Gastrointestinal & Liver Physiology Section, 2012

NIH R03 Small Research Grant Program, 2014-2016

Affiliations

Curriculum in Cell Biology and Physiology