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NGRRC

The National Gnotobiotic Rodent Resource Center is a unique and essential resource for all investigators to study physiologic and pathophysiological functions of normal and dysbiotic resident bacteria, with particular emphasis on gene-environmental interactions in genetically altered gnotobiotic mice (transgenic, knockout or spontaneously mutated) with altered physiology and disease phenotypes.

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Center Features
  1. We provide gnotobiotic mice nationally;
  2. We have a highly experienced team of technical staff who perform experimental techniques;
  3. We provide external investigators the option for onsite tissue collection;
  4. We collaborate with the UNC Mutant Mouse Regional Resource Center (MMRRC) and Collaborative Cross (CC) Consortium;
  5. We train and support external investigators to set up their own local gnotobiotic units.
Objectives
  1. Provide germ-free and gnotobiotic mice to investigators across the country;
  2. Derive mouse strains into germ-free conditions;
  3. Support new investigators to generate preliminary data for grant applications;
  4. Train personnel to develop gnotobiotic facilities at other institutions;
  5. Develop and characterize complex microbial communities and libraries of bacterial strains.