Jonathan Hansen, MD, PhD

Research Summary

Jonathan Hansen has developed a research program that studies the effects of chronic intestinal inflammation on resident intestinal microbiota. This research has been funded by organizations including the NIH, Crohn’s and Colitis Foundation, and Triangle Center for Evolutionary Medicine.  Using a multi-disciplinary approach to metagenomics, transcriptomics, whole genome sequencing, and molecular microbiology, he has made significant contributions to our understanding of the role of the microbiota in chronic intestinal inflammation. He collaborates with investigators at a number NIH digestive disease Centers including: Washington University, St. Louis, University of Chicago, and Johns Hopkins.

Relevance of Research to CGIBD Mission: Dr. Hansen’s research concerns the pathogenesis and treatment of chronic intestinal inflammatory disorders. While there is considerable research on the effect of microbes on the host, he has investigated the effect of chronic inflammation on the resident bacterial microbiota. This research has led to important insights that are directly relevant to the CGIBD mission to reduce the burden of digestive diseases.

CGIBD Focus Area(s):  Microbiome

Pilot and Feasibility Award, 2009 & 2015 

Collaborators:  Carroll, Fodor, Furey, Herfarth, Long, Maio, Sartor, Sheikh