Dr. Ehre’s laboratory specializes in the biophysical and biochemical properties of mucus, which are affected by various airway diseases such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD) and primary ciliary dyskinesia (PCD). Studies conducted in her laboratory utilize cell cultures, human specimen and animal models.
Mucus is normally produced in the lungs to trap inhaled pathogens (e.g., bacteria, viruses) and particles (e.g., dust, smoke) but, in pulmonary disease, increased mucus concentration leads to airflow obstruction, bacterial infection and chronic inflammation. Dr. Ehre’s research focuses on understanding the biological alterations of mucus that occur in disease and studying new pharmacological approaches to restore lung health. Dr. Ehre also conducts preclinical studies testing compounds aimed at improving mucus clearance in the lungs.
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