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Marsico Lung Institute/UNC Cystic Fibrosis Center

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Pseudomonas aeruginosa in artificial sputum medium with concentrated mucus

Pseudomonas aeruginosa in Artificial Sputum Medium with Concentrated Mucus.

The image shows the bacterial pathogen Pseudomonas aeruginosa, mPAO1, expressing a red fluorescent protein grown in an in vitro artificial sputum medium containing concentrated mucus for 8 hours. The P. aeruginosa assembles into bacterial aggregates similar to aggregates observed in the cystic fibrosis airway. This model allows us to understand the properties of these aggregates which help P. aeruginosa survive and adapt within the airway despite antibiotic challenge and immune-mediated clearance. Scale = 250μm

This image is from the Wolfgang Lab and was taken by Matthew Greenwald, a Graduate Student in the Department of Microbiology & Immunology.


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