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Marsico Lung Institute/UNC Cystic Fibrosis Center

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ER Stress Markers in Native CF Bronchial Epithelia

ER Stress Markers in Native CF Bronchial Epithelia.

Carla Ribeiro, PhD, presents a high-resolution immunofluorescent confocal image of native CF human bronchial epithelium depicting the ER stress markers immunoglobulin binding protein (BIP/GRP78; green), protein disulfide isomerase (PDI; red), and their overlay (yellow). Native, infected, and inflamed CF airway epithelia exhibit ER stress and activation of the Unfolded Protein Response.

Credit: Ribeiro CM, Paradiso AM, Schwab U, Perez-Vilar J, Jones L, O’neal W, Boucher RC. Chronic airway infection/inflammation induces a Ca2+i-dependent hyperinflammatory response in human cystic fibrosis airway epithelia. J Biol Chem. 2005 May 6;280(18):17798-806. doi: 10.1074/jbc.M410618200. PMID: 15746099.

Image obtained by Carla Ribeiro (

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