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  • bioRxiv

    Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

    There is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE)

  • Christoph and Alex

    New Faculty Hires

    Christoph Rau, PhD My research focuses on using model organism populations to study cardiovascular disease.  I obtained my PhD in Microbiology, Immunology and Molecular Genetics at UCLA, where I began working with the Hybrid Mouse Diversity Panel to study the genetics underlying heart failure.  In my postdoc, I expanded into studying the epigenome and developing … Continued

  • Mark Zylka

    Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

    A multidisciplinary team led by Dr. Mark Zylka shows that deletion of TOP1, an enzyme that relieves DNA stress during transcription, in neurons causes genomic instability and early onset of neurodegeneration. Read this exciting work in Nature  

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Featured Faculty

Adam PalmerAdam Palmer

Dr. Adam Palmer is an Assistant Professor in the Department of Pharmacology and Computational Medicine Program.

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Katherine HoadleyKatherine Hoadley

Dr. Katherine Hoadley is an Assistant Professor in the Department of Genetics and the Lineberger Comprehensive Cancer Center. She was recently published in Cell.

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Leadership

Timothy Elston, PhD
Charles M. Perou, PhD

The School of Medicine has launched a new Computational Medicine Program, aiming to channel UNC’s strength in computational biology, the basic sciences, and clinical research, toward making significant advances in clinical care for patients.

Co-directors of the new program are Timothy Elston, PhD, professor of pharmacology and director of the Curriculum in Bioinformatics and Computational Biology, and Charles M. Perou, PhD, the May Goldman Shaw Distinguished Professor of Molecular Oncology at the UNC Lineberger Comprehensive Cancer Center, and professor of genetics, and of pathology and laboratory medicine.

“The Computational Medicine Program will enable teams of scientists from across the university to come together to address problems related to biomedical research,” Elston said. “Our ultimate goal is to generate models, combining many different types of data, that will enable us to predict outcomes of treatment, and design new ways of thinking about treating disease.”

 

Diversity Statement

The UNC Health Care System and the UNC School of Medicine values all people throughout our organization, regardless of background, lifestyle, and culture. The Computational Medicine Program is committed to workforce diversity and inclusion in a supportive environment.