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A scientific diagram depicts the structure of the human cell cycle

Wayne Stallaert, Ph.D., Katarzyna M. Kedziora, et al., published in Cell Systems: The structure of the human cell cycle.

 

 

 

 

A diagram depicts biosensor activity

Bei Liu, Orrin J. Stone, Michael Pablo, Cody Herron, Ana T. Nogueira, Onur Dagliyan, Jonathan B. Grimm, Luke D. Lavis, Timothy C. Elston, Klaus M. Hahn, publication in Cell: Biosensors based on peptide exposure show single molecule conformations in live cells

 

 

 

 

 

Pictured are doctors Haidong Yi and Natalie StanleyHaidong Yi, Natalie Stanley, publication in bioRxiv: CytoSet: Predicting clinical outcomes via set-modeling of cytometry data

 

 

 

 

 

 

image of a laptop computerKhem Raj Ghusinga publication in PNAS: Molecular switch architecture determines response properties of signaling pathways.

 

 

 

Amy PomeroyAmy Pomeroy publication in Science Signaling: A predictive model of gene expression reveals the role of network motifs in the mating response of yeast.

 

 

 

 

 

Christoph RauRau Lab publication in PLoS Genetics: Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for “polygenic epistasis”.

 

 

 

 

Adam Palmer

 

Adam Palmer’s publication in Cancer Research: A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.

 

 

 

a scientific diagram of a bioprosthetic aortic valve Mathematics Department’s publication in Elsevier: Bioprosthetic aortic valve diameter and thickness are directly related to leaflet fluttering: Results from a combined experimental and computational modeling study.

 

p53-signaling encoded diagram results are pictured on a graphLabs: Dittmer, Damania, Baric, Heise and U. Wisconsin’s Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka’s publication of Novel modulators of p53-signaling encoded by unknown genes of emerging viruses. 

 

 

 

 

Data analytics results of data modeling in the R analytics program are pictured

Michael Love Lab published in F1000 Research ExploreModelMatrix: Interactive exploration for improved understanding of design matrices and linear models in R [version 2; peer review: 3 approved]

 

 

 

 

photograph of Maddox cells

Amy Shaub Maddox Lab posted a publication in bioRxiv: Novel cytokinetic ring components limit RhoA activity and contractility.

 

 

 

several graphical renderings are displayed of Single-cell transcriptomic reconstructs

Qian Lab’s recent publication in Nature: Single-cell transcriptomic reconstructs fate conversion from fibroblast to cardiomyocyte.

 

 

 

 

a group of scientists analyze data on a large computer screen

The recent publication using genomic and computational approaches to identify and annotate non-coding RNAs transcribed at enhancer regions known as enhancer RNAs in breast cancer cells: Enhancer transcription revealed subtype-specific gene expression programs controlling breast cancer pathogenesis.

 

 

 

a microscopic picture of brain molecules

Zylka lab, studies genetic and environmental risks for autism.  In addition, Zylka lab study molecular and brain mechanisms that underlie pain sensation.  Their long-term goal is to uncover new treatments for chronic pain and neurodevelopmental disorders, like autism, Rett syndrome and Angelman syndrome. A collection of the publications can be found on the NIH website.

 

 

 

 

an image and graph shows a rendering of cell morphogenesis

Many studies employ shape descriptors globally to probe mechanisms of cell morphogenesis. Here, we examined cell behavior very locally along the cell edge. The Hilbert-Huang transform (HHT) was used to extract spectra of instantaneous edge motion frequency and magnitude along the entire cell edge, and these were then used to classify subcellular edge sectors with distinct dynamics. When optogenetics was used to acutely inhibit specific signaling pathways, we found changes in the frequency spectra, but not in the magnitude spectra. After clustering cell edge sectors with distinct morphodynamics we observed that sectors with different frequency spectra are associated with specific signaling dynamics and motility behavior. Together these observations let us conclude that the frequency spectrum encodes the wiring of the molecular circuitry that regulates edge movements, whereas the magnitude captures the activation level of circuitry. Full results can be found in the publication: Profiling cellular morphodynamics by spatiotemporal spectrum decomposition.

 

 

A data visualization program rendering of IncRNA sequencing

Calabrese Lab developed a new method to quantify sequence similarity between evolutionarily unrelated lncRNAs. The method allows us to take sequence information from a well-studied lncRNA, and use it to discover lncRNAs that may be functioning through a related mechanism. Full results can be found in the publication: Functional classification of long non-coding RNAs by k-mer content.

 

 

 

 

a graph shows data points related to a Crohn's Disease study

MicroRNA profiling in the colon from Crohn’s disease (CD) patients revealed two distinct molecular subtypes, with miR-31 the most significantly differentially expressed between the two. Low colonic miR-31 expression levels at the time of surgery were associated with worse disease outcome in adults and with future development of fibrostenotic ileal CD requiring surgery in children. Full results can be found in the publication: Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes.

 

a plot chart shows the relation between characterized and uncharacterized kinases as part of a breast cancer research projectRecent work by the Gomez and Johnson labs has led to the discovery of multiple protein kinases and related kinome subnetworks that have distinctive behaviors across breast cancer subtypes as well as in response to drug treatment. Of note was the identification of a number of poorly understood or “dark” kinases that had highly dynamic behavior and thus may represent valuable targets for future drug development. Full results can be found in the publication: Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer