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Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

June 9, 2020

There is an urgent need for a vaccine with efficacy against SARS-CoV-2. We hypothesize that peptide vaccines containing epitope regions optimized for concurrent B cell, CD4+ T cell, and CD8+ T cell stimulation would drive both humoral and cellular immunity with high specificity, potentially avoiding undesired effects such as antibody-dependent enhancement (ADE)

Parker presents Haddow Lecture at The Institute of Cancer Research

October 22, 2019

UNC Lineberger’s Joel Parker, PhD, associate professor in the UNC School of Medicine Department of Genetics and director of cancer genetics for the UNC Lineberger Bioinformatics Core, presented the Haddow Lecture for The Institute of Cancer Research in London this year. In the lecture, he discussed novel computational methods to explore RNA sequencing data for cancer … Continued

Legant Named 2019 Packard Fellow

October 20, 2019

The David and Lucile Packard Foundation announced the 2019 class of Packard Fellow for Science and Engineering, including Wesley Legant, PhD, in the biomedical engineering and pharmacology departments. Read article here

Can scientists predict which cancer markers are likely to trigger an immune response?

September 27, 2019

UNC Lineberger’s Benjamin G. Vincent, MD, and Christof Smith, PhD.   Scientists at the University of North Carolina Lineberger Comprehensive Cancer Center have designed and validated a model for predicting what might make an effective cancer vaccine against a patient’s tumor. This finding could help overcome a significant obstacle in the development of personalized cancer … Continued

UNC School of Medicine’s Wesley Legant named Beckman Young Investigator

September 5, 2019

June 14, 2019 Wesley Legant, PhD, assistant professor in the departments of Pharmacology and Biomedical Engineering, earned this prestigious early career award for his work developing new fluorescence microscopes for rapid three-dimensional imaging. Wesley Legant, PhD, assistant professor in the Department of Pharmacology and the UNC/NCSU Joint Department of Biomedical Engineering, was named as a … Continued

Vincent Lab discovers six immune subtypes of cancer

April 8, 2019

Benjamin Vincent, MD, Assistant Professor in the School of Medicine (Hematology/Oncology) and his lab have performed a comprehensive genomics evaluation of the tumor immune microenvironment in The Cancer Genome Atlas dataset, discovering six immune subtypes of cancer. These and other findings are associated with survival and are being developed as biomarkers of immunotherapy response in multiple tumor … Continued