Projects and Cores
The UNC Chlamydia Vaccine Initiative STI CRC is made up of a synergistic, multidisciplinary group of project leaders and principal investigators with clinical and basic research expertise in STI research and a history of effective collaboration in support of a vaccine development pipeline. This CRC includes three projects supported by an Administrative Core and a Clinical Core.
Project 1: Human Responses to Candidate Chlamydial AntigensProject 1 will exploit responses of women highly exposed to CT to identify candidate vaccine antigens through profiling of CD4 and CD8 T-cell responses.
Project 2: Chlamydial Vaccine Testing in Mice and Guinea PigsProject 2 will explore the efficacy of two leading T cell vaccine modalities proven safe and effective in humans as a route to establishing lasting immunity to chlamydia challenge.
Project 3: Biomarkers of Chlamydial Susceptibility and DiseaseProject 3 addresses a critical need for biomarkers to accelerate rational vaccine design and testing by supporting identification of individuals most likely to benefit from immunization.
Administrative Core The Administrative Core oversees the scientific and programmatic goals of the UNC-CVI. This Core works closely with the project investigators to ensure integration of the diverse data sets generated from the Clinical Core and Projects 1-3.
Clinical CoreThe Clinical Core of the UNC-CVI will collect clinical specimens required by the investigators for projects. This Core is made of personnel as well as research and clinical facilities that focus on providing STI-focused care to young women.