Meet the investigators involved with epigenetics research:
The work in the Magnuson lab focuses on the role of mammalian genes in unique epigenetic phenomena such as genomic imprinting, X-chromosome inactivation, stem cell pluripotency and the tumor suppressor role of chromatin remodeling complexes.
Our lab is addressing how histone post-translational modifications, and the combinatorial codes they create, contribute to the structure and function of chromatin.
Our laboratory studies how epigenetic marks influence chromosome territories and dynamics.
The Calabrese lab studies the mechanisms through which long noncoding RNAs regulate epigenetic states in normal and cancerous genomes.
Development and application of novel systems biology (functional proteomics) approaches to characterize phenotypic epigenetic protein machinery that impact gene regulation.
Our lab is studying the protein complexes involved in gene regulation in vertebrate heart development and human congenital heart disease.
DNA replication origin licensing and chromatin in metazoans
The Crona lab is interested in characterizing the clinical pharmacology (pharmacokinetics, pharmacodynamics, germline pharmacogenetics) of epigenetic pharmacotherapeutics used in the treatment of cancer.
Through the use of genome-wide approaches, the Davis lab is interested in basic and translational aspects of chromatin biology in cancer and development.
Three-dimensional genome architecture and gene regulation
Epigenetic control of DNA replication and cell proliferation during animal development
Molecular, cellular and bioinformatic dissection transcriptional enhancers and enhancer RNAs in cancer
The Frye lab is focused on discovery and validation of high-quality chemical probes for methylysine reader proteins.
My computational genomics group is focused on understanding the interplay of genetic variation, chromatin structure, and gene regulation in the context of complex traits and disease.
Contribution of epigenetics dynamics in the regulation of alternative splicing in development and cell differentiation
Our lab examines dynamic chromatin regulatory pathways in mammalian cells using novel chemical tools and inhibitors.
DNA methylation epigenetic stability and heritability
The Kim Lab is focused on understanding the genetic and epigenetic events involved in the initiation and progression of renal cell carcinoma (RCC) and bladder cancer.
Computational biophysics of the histone code and computer-aided design of chemical probes
We are interested in understanding how dysregulation of cancer signaling leads to tumorigenesis, including but not limited to, how E3 ubiquitin ligases recognize epigenetic markers using their PHD, WD40 or RING domains to control transcription and genome stability.
We study the epigenetics of cell division using high-resolution imaging
The overall goal of our laboratory is to obtain new insights into the host-virus interaction, particularly in HIV infection, and translate discoveries in molecular biology and virology to the clinic to aid in the treatment of HIV infection
Regulation of histone gene expression balancing variant and canonical histones
Epigenetic regulation of gene expression
Epigenetic basis of toxicant exposure-related susceptibility and disease
The McGinty lab uses protein chemistry and structural biology to understand mechanisms underlying signaling through chromatin in health and disease.
genomics of gene regulation in development
We identify genetic variants that influence chromatin structure and complex metabolic traits such as diabetes and obesity
The Pattenden lab is focused on developing techniques in chromatin-based therapeutic discovery and cancer diagnostics.
We use a combination of genomics, proteomics, genome editing, and bioinformatics to characterize and functionally interrogate DNA looping during monocyte differentiation.
Epigenetic mechanisms of direct cardiac reprogramming
Our lab is interested in how changes to the composition of chromatin remodeling complexes are regulated, how their disruption affects their function, and contributes to disease.
We identify genetic variation that influences chromatin structure during the development of the human brain.
Epigenetic and transcriptional regulation in T cell differentiation, function and disease.
We study chromatin marks (with emphasis on DNA methylation and histone modification), the systems that read, write and modify these marks, and their impact on biological outcomes.
Our group focuses on mechanistic understandings of how chemical modifications of chromatin define distinctive epigenomes, control gene expression, and regulate cellular fates during development, and how their deregulations lead to human diseases such as cancer, developmental disorders, and aging.
The Waters group is developing novel sensing methodology for methylated Lys and Arg.
My laboratory focuses on how aberrant SWI/SNF chromatin remodeling activity contributes to human tumor development.
My laboratory uses biophysical and structural analyses to study the methyl-cytosine binding domain family of proteins and the NuRD chromatin remodeling complex.
We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.
Our lab is studying the role of TET enzymes and DNA demethylation in chromatin regulation
Our lab seeks to uncover the epigenetic mechanisms linking psychosocial stress with disease risk