Meet the investigators involved with epigenetics research:
Co-Director
The work in the Magnuson lab focuses on the role of mammalian genes in unique epigenetic phenomena such as genomic imprinting, X-chromosome inactivation, stem cell pluripotency and the tumor suppressor role of chromatin remodeling complexes.
Co-Director
Our lab is addressing how histone post-translational modifications, and the combinatorial codes they create, contribute to the structure and function of chromatin.
Our laboratory studies how epigenetic marks influence chromosome territories and dynamics.
The Calabrese lab studies the mechanisms through which long noncoding RNAs regulate epigenetic states in normal and cancerous genomes.
Development and application of novel systems biology (functional proteomics) approaches to characterize phenotypic epigenetic protein machinery that impact gene regulation.
Our lab is studying the protein complexes involved in gene regulation in vertebrate heart development and human congenital heart disease.
DNA replication origin licensing and chromatin in metazoans
The Crona lab is interested in characterizing the clinical pharmacology (pharmacokinetics, pharmacodynamics, germline pharmacogenetics) of epigenetic pharmacotherapeutics used in the treatment of cancer.
Through the use of genome-wide approaches, the Davis lab is interested in basic and translational aspects of chromatin biology in cancer and development.
Three-dimensional genome architecture and gene regulation
Epigenetic control of DNA replication and cell proliferation during animal development
Molecular, cellular and bioinformatic dissection transcriptional enhancers and enhancer RNAs in cancer
Contribution of epigenetics dynamics in the regulation of alternative splicing in development and cell differentiation
We study epigenetic regulation of lung fibroblast phenotypes in the context of lung development and lung fibrosis.
Our lab examines dynamic chromatin regulatory pathways in mammalian cells using novel chemical tools and inhibitors.
DNA methylation epigenetic stability and heritability
We are interested in modulating the activity of chromatin reader proteins with small molecule chemical probes or bivalent chemical degraders in order to open new avenues of research in the fields of chromatin and cancer biology and potentially translate to compounds of therapeutic value.
We study epigenetic regulation of HIV transcription and latency in CD4+ T cells as well as non-T cells, with a focus of protein crotonylation.
The Jothi lab is focused on mechanistic understanding of how transcription factors and chromatin remodeling complexes regulate gene expression programs controlling cell fate decisions during normal development and cancer.
The Kim Lab is focused on understanding the genetic and epigenetic events involved in the initiation and progression of renal cell carcinoma (RCC) and bladder cancer.
We try to understand the mechanism by which chromatin folding is regulated and how it affects gene transcription.
We are interested in understanding how dysregulation of cancer signaling leads to tumorigenesis, including but not limited to, how E3 ubiquitin ligases recognize epigenetic markers using their PHD, WD40 or RING domains to control transcription and genome stability.
We study the epigenetics of cell division using high-resolution imaging
The overall goal of our laboratory is to obtain new insights into the host-virus interaction, particularly in HIV infection, and translate discoveries in molecular biology and virology to the clinic to aid in the treatment of HIV infection
Regulation of histone gene expression balancing variant and canonical histones
Epigenetic regulation of gene expression
The McGinty lab uses protein chemistry and structural biology to understand mechanisms underlying signaling through chromatin in health and disease.
genomics of gene regulation in development
We are interested in exploring the epigenetic and transcriptional mechanisms regulating T cell activity during infection and cancer, especially in the context of immunotherapies.
We identify genetic variants that influence chromatin structure and complex metabolic traits such as diabetes and obesity
The Morris Lab studies epigenetic and genomic mechanisms that connect cancer driver mutations to cell fate transitions during tumor development.
The Pattenden lab is focused on developing techniques in chromatin-based therapeutic discovery and cancer diagnostics.
We use a combination of genomics, proteomics, genome editing, and bioinformatics to characterize and functionally interrogate DNA looping during monocyte differentiation.
Epigenetic mechanisms of direct cardiac reprogramming
Our lab is interested in how changes to the composition of chromatin remodeling complexes are regulated, how their disruption affects their function, and contributes to disease.
The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription during development with relevance to human disorders.
We identify genetic variation that influences chromatin structure during the development of the human brain.
Epigenetic and transcriptional regulation in T cell differentiation, function and disease.
We study chromatin marks (with emphasis on DNA methylation and histone modification), the systems that read, write and modify these marks, and their impact on biological outcomes.
Our group focuses on mechanistic understandings of how chemical modifications of chromatin define distinctive epigenomes, control gene expression, and regulate cellular fates during development, and how their deregulations lead to human diseases such as cancer, developmental disorders, and aging.
The Waters group is developing novel sensing methodology for methylated Lys and Arg.
My laboratory focuses on how aberrant SWI/SNF chromatin remodeling activity contributes to human tumor development.
My laboratory uses biophysical and structural analyses to study the methyl-cytosine binding domain family of proteins and the NuRD chromatin remodeling complex.
Our lab seeks to uncover the epigenetic mechanisms linking psychosocial stress with disease risk