Jill Dowen, PhD
Chromatin and Epigenetics Leadership Committee
Three-dimensional genome architecture and gene regulation
Faculty
Meet the investigators involved with epigenetics research:
Leadership
Terry Magnuson, PhD
Chromatin and Epigenetics Leadership Committee
The work in the Magnuson lab focuses on the role of mammalian genes in unique epigenetic phenomena such as genomic imprinting, X-chromosome inactivation, stem cell pluripotency and the tumor suppressor role of chromatin remodeling complexes.
Robert McGinty, MD, PhD
Chromatin and Epigenetics Leadership Committee
The McGinty lab uses protein chemistry and structural biology to understand mechanisms underlying signaling through chromatin in health and disease.
Samantha Pattenden, PhD
Chromatin and Epigenetics Leadership Committee
Techniques in chromatin-based therapeutic discovery and cancer diagnostics.
Brian Strahl, PhD
Chromatin and Epigenetics Leadership Committee
Our lab is addressing how histone post-translational modifications, and the combinatorial codes they create, contribute to the structure and function of chromatin.
Members
Trevor Archer, PhD
Our research group studies the interplay of chromatin and epigenetics in stem cell and cancer biology with a focus on epigenetic responses to physiological and environmental exposures.
Kerry Bloom, PhD
Our laboratory studies how epigenetic marks influence chromosome territories and dynamics.
J. Mauro Calabrese, PhD
The Calabrese lab studies the mechanisms through which long noncoding RNAs regulate epigenetic states in normal and cancerous genomes.
Xian Chen, PhD
Development and application of novel systems biology (functional proteomics) approaches to characterize phenotypic epigenetic protein machinery that impact gene regulation.
Frank L. Conlon, PhD
Our lab is studying the protein complexes involved in gene regulation in vertebrate heart development and human congenital heart disease.
Jean Cook, PhD
DNA replication origin licensing and chromatin in metazoans
Daniel Crona, PharmD, PhD
The Crona lab is interested in characterizing the clinical pharmacology (pharmacokinetics, pharmacodynamics, germline pharmacogenetics) of epigenetic pharmacotherapeutics used in the treatment of cancer.
Ian J. Davis, MD, PhD
Through the use of genome-wide approaches, the Davis lab is interested in basic and translational aspects of chromatin biology in cancer and development.
Bob Duronio, PhD
Epigenetic control of DNA replication and cell proliferation during animal development
Jimena Giudice, PhD
Contribution of epigenetics dynamics in the regulation of alternative splicing in development and cell differentiation
Jim Hagood MD
We study epigenetic regulation of lung fibroblast phenotypes in the context of lung development and lung fibrosis.
Nathan A. Hathaway, PhD
Our lab examines dynamic chromatin regulatory pathways in mammalian cells using novel chemical tools and inhibitors.
Folami Ideraabdullah, PhD
DNA methylation epigenetic stability and heritability
Lindsey I. James, PhD
We are interested in modulating the activity of chromatin reader proteins with small molecule chemical probes or bivalent chemical degraders in order to open new avenues of research in the fields of chromatin and cancer biology and potentially translate to compounds of therapeutic value.
Guochun Jiang, PhD
We study epigenetic regulation of HIV transcription and latency in CD4+ T cells as well as non-T cells, with a focus of protein crotonylation.
Raja Jothi, PhD
The Jothi lab is focused on mechanistic understanding of how transcription factors and chromatin remodeling complexes regulate gene expression programs controlling cell fate decisions during normal development and cancer.
William Y. Kim, MD
The Kim Lab is focused on understanding the genetic and epigenetic events involved in the initiation and progression of renal cell carcinoma (RCC) and bladder cancer.
Wonho Kim, PhD
We try to understand the mechanism by which chromatin folding is regulated and how it affects gene transcription.
Wesley Legant, PhD
Our lab uses advanced imaging approaches and biophysical modeling to study chromatin structure and dynamics.
Pengda Liu, PhD
We are interested in understanding how dysregulation of cancer signaling leads to tumorigenesis, including but not limited to, how E3 ubiquitin ligases recognize epigenetic markers using their PHD, WD40 or RING domains to control transcription and genome stability.
Paul S. Maddox, PhD
We study the epigenetics of cell division using high-resolution imaging
David Margolis, MD
The overall goal of our laboratory is to obtain new insights into the host-virus interaction, particularly in HIV infection, and translate discoveries in molecular biology and virology to the clinic to aid in the treatment of HIV infection
William F. Marzluff, PhD
Regulation of histone gene expression balancing variant and canonical histones
A. Greg Matera, PhD
Epigenetic regulation of gene expression
Daniel J. McKay, PhD
genomics of gene regulation in development
Justin Milner
We are interested in exploring the epigenetic and transcriptional mechanisms regulating T cell activity during infection and cancer, especially in the context of immunotherapies.
Karen L. Mohlke, PhD
We identify genetic variants that influence chromatin structure and complex metabolic traits such as diabetes and obesity
John P. Morris IV
The Morris Lab studies epigenetic and genomic mechanisms that connect cancer driver mutations to cell fate transitions during tumor development.
Douglas H. Phanstiel, PhD
We use a combination of genomics, proteomics, genome editing, and bioinformatics to characterize and functionally interrogate DNA looping during monocyte differentiation.
Kevin Pruitt, PhD
The Pruitt lab is interested in defining how DNA methylation readers are regulated and contribute to cancer-linked immunosuppression. Second, we are exploring how Dishevelled proteins, which are master regulators of Wnt signaling, impact the epigenome.
Li Qian, PhD
Epigenetic mechanisms of direct cardiac reprogramming
Jesse Raab, PhD
Our lab is interested in how changes to the composition of chromatin remodeling complexes are regulated, how their disruption affects their function, and contributes to disease.
Karl Shpargel, PhD
The Shpargel laboratory studies the coordination of histone-modifying enzymes in regulating chromatin structure, enhancer activation, and transcription during development with relevance to human disorders.
Jason Stein, PhD
We identify genetic variation that influences chromatin structure during the development of the human brain.
Ageliki Tsagaratou, PhD
Epigenetic and transcriptional regulation in T cell differentiation, function and disease.
Paul A. Wade, PhD
We study chromatin marks (with emphasis on DNA methylation and histone modification), the systems that read, write and modify these marks, and their impact on biological outcomes.
Marcey Waters, PhD
The Waters group is developing novel sensing methodology for methylated Lys and Arg.
Jason Watts, PhD
We study how nucleic acid structure and chromatin environment influence RNA polymerase pausing in renal and other human diseases.
David C. Williams, Jr., MD, PhD
My laboratory uses biophysical and structural analyses to study the methyl-cytosine binding domain family of proteins and the NuRD chromatin remodeling complex.
Anthony S. Zannas, MD, PhD
Our lab seeks to uncover the epigenetic mechanisms linking psychosocial stress with disease risk