How can we best utilize genome-scale sequencing as a clinical diagnostic test? What are the most effective ways of sifting through many thousands of genetic variants to find the few variants that are clinically relevant for the patient? How should we manage the inevitable “incidental findings” that will be present in every genome-scale sequencing assay? These are some of the questions being asked in the NHGRI-funded U01 project called “NCGENES” led by Dr. Jim Evans in the Department of Genetics.