How can next-generation sequencing be most effectively employed to enhance current newborn screening? What types of genes and conditions should be sought in a healthy newborn? How should parents decide what information they would want to know or not to know? Are there certain types of information that should be withheld until the individual becomes an adult and chooses to know or not to know? We are exploring these issues and others in an NHGRI/NICHD-funded U21 project called “NC NEXUS” led by myself and co-PI Dr. Cindy Powell from the Department of Pediatrics, Division of Pediatric Genetics and Metabolism.