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2022

  • Burclaff J, Bliton RJ, Breau KA, Ok MT, Gomez-Martinez I, Ranek JS, Bhatt AP, Purvis JE, Woosley JT, Magness ST. A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics. (2022) Cellular and Molecular Gastroenterology and Hepatology Feb 14:S2352-345X(22)00034-0. PMID: 35176508.
  • Mei L, Kedziora KM, Song EA, Purvis JE, Cook JG. The consequences of differential origin licensing dynamics in distinct chromatin environments. (2022) Nucleic Acids Research Jan 26:gkac003. PMID: 35079814.

2021

  • Enrico TP, Stallaert W, Wick ET, Ngoi P, Wang X, Rubin SM, Brown NG, Purvis JE, Emanuele MJ. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. (2021) Elife 10:e70691. PMID: 34851822.
  • Stallaert W, Kedziora KM, Taylor CD, Zikry TM, Ranek JS, Sobon HK, Taylor SR, Young CL, Cook JG, Purvis JE. The structure of the human cell cycle. (2021) Cell Systems S2405-4712(21)00418-X. PMID: 34800361.
  • Haggerty RA, Purvis JE. Inferring the structures of signaling motifs from paired dynamic traces of single cells. (2021) PLoS Computational Biology 17(2):e1008657. PMID: 33539338.

2020

  • Kumar RJ, Chao HX, Simpson DA, Feng W, Cho MG, Roberts VR, Sullivan AR, Shah SJ, Wozny AS, Fagan-Solis K, Kumar S, Luthman A, Ramsden DA, Purvis JE, Gupta GP. Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. (2020) Nucleic Acids Research Cancer 2(4):zcaa038. PMID: 33385162.
  • Coryell PR, Goraya SK, Griffin KA, Redick MA, Sisk SR, Purvis JE. Autophagy regulates the localization and degradation of p16INK4a. (2020) Aging Cell 19(7):e13171. PMID: 32662244.

2019

  • Stallaert W, Kedziora KM, Chao HX, Purvis JE. Bistable switches as integrators and actuators during cell cycle progression. (2019) FEBS Letters 593(20):2805. PMID: 31566708.
  • Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Genetic determinants of cellular addiction to DNA polymerase theta. (2019) Nature Communications 10(1):4286. PMID: 31537809.
  • Headley KM, Kedziora KM, Alejo A, Lai EZ, Purvis JE, Hathaway NA. Chemical screen for epigenetic barriers to single allele activation of Oct4. (2019) Stem Cell Research 38:101470. PMID: 31170660.
  • Zikry TM, Kedziora KM, Kosorok MR, Purvis JE. In and out of the nucleus: CNN based segmentation of cell nuclei from images of a translocating sensor. (2019) Proceedings of the Practice and Experience in Advanced Research ComputingView PDF.
  • Wolff SC, Purvis JE. Reprogramming favors the elite. (2019) Science 364(6438):330-331. PMID: 31023911.

2018

  • Chao HX, Fakhreddin RI, Shimerov HK, Kedziora KM, Kumar RJ, Perez J, Limas JC, Grant GD, Cook JG, Gupta GP, Purvis JE. Evidence that the human cell cycle is a series of uncoupled, memoryless phases. (2018) Molecular Systems Biology 15(3):e8604. PMID: 30886052.
  • Grant GD, Kedziora KM, Limas JC, Cook JG, Purvis JE. Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI. (2018) Cell Cycle17(21-22):2496-2516. PMID: 30421640.
  • Wolff SC, Kedziora KM, Dumitru R, Dungee CD, Zikry TM, Beltran AS, Haggerty RA, Cheng J, Redick MA, Purvis JE. Inheritance of OCT4 predetermines fate choice in human embryonic stem cells. (2018) Molecular Systems Biology 14(9):e8140. PMID: 30177503.
  • Borland D, Yi H, Grant GD, Kedziora KM, Chao HX, Haggerty RA, Kumar J, Wolff SC, Cook JG, Purvis JE. The Cell Cycle Browser: An Interactive Tool for Visualizing, Simulating, and Perturbing Cell-Cycle Progression. (2018) Cell Systems 7(2):180-184.e4. PMID: 30077635.

2017

  • Haggerty RA, Purvis JE. Natural language processing: put your model where your mouth is. (2017) Molecular Systems Biology 13(12):958. PMID: 29254950. View PDF
  • Chao HX, Poovey CE, Privette AA, Grant GD, Chao HY, Cook JG, Purvis JE. Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle. (2017) Cell Systems 5(5):445-459.e5. PMID: 29102360. View PDF
  • Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG. Rapid DNA replication origin licensing protects stem cell pluripotency. (2017) Elife 6. pii: e30473. PMID: 29148972. View PDF
  • Kedziora KM, Purvis JE. Cell biology: The persistence of memory. (2017) Nature 549(7672):343-344. PMID: 28869963. View PDF

2016

  • Baran-Gale J, Purvis JE*, Sethupathy P*. An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells. (2016) RNA 22(10):1592-603. PMID: 27539783. View PDF

2015

  • Coleman KE, Grant GD, Haggerty RA, Brantley K, Shibata E, Workman BD, Dutta A, Varma D, Purvis JE, Cook JG. Sequential replication-coupled destruction at G1/S ensures genome stability. (2015) Genes and Development 29(16):1734. PMCID: PMC4561482. View PDF
  • Davis DM, Purvis JE. Computational analysis of signaling patterns in single cells (2015) Seminars in Cell and Developmental Biology Jan; 37:35-43. View PDF

2014

  • Gorman BR, Lu J, Baccei A, Lowry NC, Purvis JE, Mangoubi RS, Lerou PH. Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis. (2014) PLoS ONE 9(12):e116037. PMID: 25551762. View PDF