Category: News
The Sensory Experiences Project
To examine the development, functional impact, and cause of various sensory features in children with autism, developmental delay, and/or typical development, ages 2-12 years. SEP is part of the PEARLS program (Program in Early Autism Research, Leadership and Service) at UNC.
A Multilinguistic Analysis of Spelling Errors among Children with Hearing Loss
Children with hearing loss face a variety of developmental challenges in the domains of language and literacy, including spelling. The purpose of the proposed study is to investigate the impact of linguistic sources of knowledge on spelling among children with hearing loss, utilizing a multilinguistic analytic approach that reflects recent theoretical and empirical understandings … Read more
Variation in Sweat Testing Analysis: PTC VISTA
Sweat chloride determinations are used to confirm the diagnosis of CF and also serve as a biomarker for CFTR gene function in clinical trials using protein modulation therapy. Currently, there is uncertainty surrounding the appropriate degree of change in sweat chloride concentrations which reflects a positive response to an investigational drug. Being able to assess a meaningful … Read more
Autism Spectrum Disorder State Implementation Project
The goal of this project is to increase the collaboration among public and private agencies in the state of North Carolina in order to improve screening, assessment, diagnosis, and early intervention for children suspected of ASD ages birth to 5.
Executive Function in Pediatric Hypertension
The goal of this multisite study is to investigate the relationship between primary hypertension and executive function as a novel, emerging target of hypertensive damage in children.
Improving sweat testing performance: a multi-center collaborative initiative towards earlier diagnosis of infants with CF and positive CF newborn screening tests
We aim to reduce sweat testing quantity not sufficient (QNS) rates in infants who are referred to Cystic Fibrosis Foundation Accredited Care Centers for follow-up testing after a positive newborn screening (NBS) test. It is important to do this now because there is evidence of both high QNS rates at some centers. Additionally a significant percentage of infants diagnosed with CF … Read more
Early Development Project-2
Title: Efficacy of a Parent-Mediated Intervention for One-Year-Olds at-Risk for Autism (Early Development Project-2) Purpose: To assess the efficacy of an early intervention program called Adaptive Responsive Teaching in improving developmental outcomes and ameliorating symptom severity among one-year-olds at-risk for autism spectrum disorders (i.e., “autism”). Setting: The resea … Read more
Behavioral Inflexibility in IDD: Outcome Measurement
This RO1 application requests funds to develop and validate a novel outcome measure targeting the behavioral inflexibility in children with intellectual and developmental disabilities (IDD). This behavioral domain encompasses a host of closely related clinical sequelae that can be profoundly disabling and are common in IDD such as (a) an overall inflexible temperament or behavior … Read more
Occupational Needs of Women in the Acute Post-Operative Phase After Gynecologic Oncology Procedures
The primary treatment modality for ovarian cancer is radical surgery. Rates of post-operative morbidity (20-30%) and hospital readmission (10-15%) are high. Low QOL prior to chemotherapy (i.e. after surgery) is associated with delayed chemotherapy start, dose delays, and decreased overall survival. The quality of surgical recovery in this population is high-stakes, with an impact … Read more
Attention in Girls with Autism Spectrum Disorder (ASD): An Eye-Tracking Approach to Gender-Specific Circumscribed Interests
ASD is a male-dominant condition however research indicates that girls may have different phenotypic-profiles particularly in the domain of Circumscribed Interests (CI) – intense and often idiosyncratic interest held by children and adults with ASD. CI are reported in 80% of individuals with ASD, and while can represent islands of ability, limit learning and social opportunities. … Read more