iPSCs · Genome editing · Cell differentiation · Organoids
Human iPSC and organoid models for discovery and translational research
The Human Pluripotent Cell Core (HPCC) partners with investigators to develop physiologically relevant human cell models. Our integrated capabilities span reprogramming, genome engineering, clonal selection, directed differentiation and organoid development. Project design, quality-control criteria, and deliverables are defined collaboratively to support rigorous, reproducible discovery and translational research.
Serving academic and industry researchers nationwide · RRID: SCR_023246
Services we offer
iPSC generation from fibroblasts and PBMCs; expansion, characterization, and banking.
Genome editing
CRISPR knock-in/knockout, reporter lines, and isogenic disease/control models
Assay development
Custom functional endpoints for disease modeling and screening
Differentiation
Neurons, astrocytes, cardiomyocytes, hepatocytes, endothelial cells, neutrophils, and microglia
Organoids
Brain, liver, and kidney organoids, including vascularized and immune-component systems
Banking
Cryopreservation, storage, QC, and distribution of lines and differentiated products
Human-Relevant Models and New Approach Methodologies (NAMs)
HPCC develops iPSC-derived cells, engineered reporter lines, organoids, and screening-ready human model systems for disease modeling, drug discovery, toxicology, and NAM research. We work with investigators to define the model, controls, quality criteria, functional endpoints, and reproducibility strategy appropriate to the intended experimental use.
How it works
01
Tell us what you need. Free consultation on design and feasibility.
02
We scope it. Written plan, timeline, and cost before work begins.
03
Order through iLab.
04
Receive your cells with a complete QC data package.
About the core
The UNC Human Pluripotent Cell Core (HPCC) provides centralized expertise, shared infrastructure, and collaborative support for human pluripotent stem cell research. We work with investigators at UNC, across the Research Triangle, and nationwide, from initial concept and feasibility assessment through experimental implementation, with an emphasis on rigor, reproducibility, and responsible research practices.