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Brian Colwell Jensen, MD - Division of Cardiology

Brian Colwell Jensen, MD

Professor of Medicine

Contact Information



McAllister Heart Institute, UNC School of Medicine, Division of Cardiology:
3341B Medical Biomolecular Research Building, 111 Mason Farm Rd.
Chapel Hill, NC 27599
UNC Cardiology at Eastowne:
100 Eastowne Drive
Chapel Hill, NC 27514


Brian Colwell Jensen, MD

Professor of Medicine

Areas of Interest

Advanced heart failure, cardio-oncology, myocardial biology, alpha-1 adrenergic receptors, kinase inhibitor cardiotoxicity, cardiomyocyte mitochondrial function and metabolism


I am a physician-scientist with a clinical and investigative focus on heart failure. I have subspecialty clinical certification in Advanced Heart Failure/Transplantation and serve as an attending physician on the UNC Heart Failure/Transplant/LVAD inpatient service. I also direct the UNC cardio-oncology clinic.

My laboratory uses basic and translational approaches to study heart failure and the molecular response to myocardial injury. The primary projects in my laboratory focus on (1) Understanding how alpha-1A adrenergic receptors adaptively regulate cardiomyocyte metabolism and developing an alpha-1A adrenergic receptor agonist to treat heart failure; (2) Determining the mechanisms underlying cardiotoxicity of cytotoxic and targeted cancer therapies; and (3) Identifying cardioprotective roles for the nuclear receptor ROR-alpha in regulating cardiomyocyte metabolism and inflammation.

  • Undergraduate

    Pomona College

  • Medical School

    University of North Carolina at Chapel Hill

  • Residency

    Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

  • Cardiology Fellowship

    University of California, San Francisco