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Medicine Grand Rounds, Claire M. Doerschuk “Pneumonia: Homeland Security in the Lungs!”
December 1, 2016 @ 12:00 pm - 1:00 pm
Dr. Doerschuk’s Grand Rounds will focus on host defense in the lungs, particularly how the lungs defend themselves against common stimuli such as bacterial pathogens and tobacco smoke. Airway epithelial cells, lung macrophages and neutrophils contribute to host defense. These cells and the processes they regulate synergize to result in an integrated response. This response can go awry in many ways, which often inform us about important mechanisms. Therapeutic interventions hold potential at many steps in this response.
Dr. Doerschuk’s research addresses host defense mechanisms in the lungs, particularly the inflammatory and innate immune processes that are important in the pathogenesis and course of bacterial pneumonia, acute lung injury/acute respiratory distress syndrome, and cigarette-smoke induced lung disease. Basic and translational studies address the mechanisms of host defense during pneumonia that focus on leukocyte recruitment, edema, and lung injury. These studies investigate pathogens that cause community-acquired and nosocomial pneumonias occurring in immunocompromised patients with cancer. Although these processes are important in all inflammatory lung diseases, her work particularly addresses pneumonia and the acute respiratory distress syndrome using in vivo, translational, cell biological, immunological, and molecular approaches. Her ultimate goal is to use this knowledge to develop therapies that enhance the inflammatory response when it is beneficial to the host and dampen this response when it is harmful.