Medicine Grand Rounds, Bryan Roth, “G-Coupled Protein Receptors”

Bryan Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics in the Department of Pharmacology. He is a world-renowned scientist best known for creating an innovative scientific method that allows neuroscientists to manipulate and study brain circuits in health and disease.

G-protein coupled receptors (GPCRs) represent one of the most evolutionarily diverse superfamilies of the human genome. Roth’s lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. Currently they are focused on members of the serotonin (5-hydroxytryptamine; 5-HT) and opioid receptor families and their accessory proteins.

Roth is also a Professor in the UNC Eshelman School of Pharmacy. He has published more than 400 articles in many prestigious journals, including Science, Nature, Cell, and The New England Journal of Medicine.