McAllister Heart Institute Seminar Series: Francis Miller, MD, Role of Smooth Muscle Cell NADPH Oxidase in Vascular Disease

Speaker: Francis J. Miller, MD, Professor of Medicine, Dept. of Internal Medicine, Division of Cardiology, Duke University School of Medicine
Topic: Role of Smooth Muscle Cell NADPH Oxidase in Vascular Disease

Information from Dr. Miller on his lecture:
The primary goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease. The objectives of my seminar are:
1) Describe the role of inflammation and oxidative stress in the development of vascular disease.
2) Describe the structure and function of the vascular NADPH oxidases in the blood vessel.
3) Discuss the role of phosphorylation and endocytosis in activation of the Nox1 NAPDH oxidase.
4) Discuss the regulation of Nox4 NADPH oxidase by miRNA and its role in smooth muscle cell differentiation.
Describe novel approaches for targeting smooth muscle cell Nox1 in vascular disease.