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Midget Distinguished Professor of Medicine (GI) Microbiology & Immunology Director, National Gnotobiotic Rodent Resource Center (NIH P40OD010995) Co-Director, Center for Gastrointestinal Biology and Disease (NIH P30DK034987) Director, Basic Science Training Program (NIH T32DK07737)

Areas of Interest

Management and education of IBD patients. Mechanisms of microbial/mucosal immune responses mediating mucosal homeostasis vs inflammation. Therapeutic microbial manipulations, risk factors for postoperative recurrence of Crohn’s disease

About

My current research emphasizes mechanisms by which resident bacterial subsets stimulate protective vs inflammatory mucosal immune responses. I use established and novel gnotobiotic murine models to identify protective vs aggressive resident bacterial subsets and to determine their mechanisms of action. We explore functional consequences of microbial communities in selectively colonized gnotobiotic mice and following fecal transplants using murine or human donors. Major initiatives explore therapeutic potential of existing and novel bacterial consortia in preclinical models, including humanized mice colonized by pooled IBD fecal transplants. The effect of diet on bacterial metabolic function/bacterial interaction are recent areas of interest. Parallel translational studies in IBD patients explore microbial biomarkers that identify risk of recurrence after Crohn’s disease surgery and onset of pouchitis after colectomy for ulcerative colitis. Mentoring and, career development are very meaningful activities for me. Fellowship training one-on-one in my laboratory and by directing a Basic Science T32 program and mentoring junior faculty are priorities.

Education and Training

  • Undergraduate Washington and Lee University (BS) 1971 Phi Beta Kappa
  • Medical School Baylor College of Medicine (MD) – 1974 Honors
  • Residency Baylor College of Medicine 1977 – Internal Medicine
  • Fellowship University of North Carolina 1981 – GI Clinical and Research

Chance favors the prepared mind. – Louis Pasteur