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Boyce Griffith, Ph.D.Congratulations to the Lab of Boyce Griffith, Ph.D., Associate Professor of Mathematics, Adjunct Associate Professor of Applied Physical Sciences & Biomedical Engineering, in collaboration with Thomas G. Caranasos, M.D., Director, Adult Cardiac Surgery; Assistant Professor of Surgery, John P. Vavalle, M.D., Assistant Professor of Medicine; Medical Director, UNC Structural Heart Disease Program; Associate Program Director, Cardiovascular Disease Fellowship Program & Interventional Cardiovascular Fellowship Program, and Alisa Wolberg, Ph.D., Professor, Pathology and Laboratory Medicine, and in partnership with the University of California-Irvine and the University of Utah, for the receipt of R01 grant from the NIH.

Thomas G. Caranasos, M.D.John P. Vavalle, M.D.Alisa Wolberg, Ph.D.The grant is a multi-principle investigator (PI) award, titled “Leaflet Thrombosis Following Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement (SAVR)”. The goal of this project is to devise and validate patient-specific computational fluid-structure interaction models of bioprosthetic heart valves coupled to biochemically and biophysically detailed thrombosis models to characterize the mechanisms that lead to leaflet thrombosis and, ultimately, to predict potential leaflet thrombosis, using clinical data in patients undergoing TAVR or SAVR.