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Anne Marion Taylor’s lab publishes in Nature Communications on the cellular mechanisms of circuit remodeling following axon damage in the mammalian central nervous system.

Anton Lab Researchers pinpoint signaling problems in the progenitor cells crucial for proper neuron generation and organization.

As part of a five-year, $7.5 million award, UNC researchers led by Joseph Piven, MD, will follow up on innovative imaging studies to create interventions to help children with autism.

The National Institute on Aging awarded a $2.6-million, five-year grant to UNC’s Mohanish Deshmukh’s lab to explore miR-29, a key molecule that helps mature brain cells avoid death.

In a first-of-its-kind study, UNC researchers show how a damaging cascade of events inside brain cells – and related to Alzheimer’s disease – can be stopped or reversed.

The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle...

The focus of this grant is to illuminate a novel mechanism for dendritic spine pruning in the mammalian neocortex by immunoglobulin (Ig)-class cell adhesion molecules and secreted Semaphorins. The overall goal is to identify mechanisms that govern synaptic connectivity in the mammalian neocortex, and to elucidate how their deficiency contributes...

Microcephaly is a hallmark of Angelman syndrome (AS), a debilitating neurodevelopmental disorder that results from loss of function of the HECT domain E3 ubiquitin ligase, UBE3A. However, until recently, the underlying causes of slowed brain growth in individuals with AS had gone unstudied, resulting in significant gaps in understanding of...

An antenna-like structure on cells, once considered a useless vestige, appears to be important for proper brain development in mammals and when impaired can cause defects in the brain’s wiring similar to what’s seen in autism, schizophrenia, and other neuropsychiatric disorders. In lab experiments, UNC School of Medicine scientists prevented...

The Cohen Lab and NC State researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.