Tag: Publication

In a paper published in Cell, UNC School of Medicine researchers led by Bryan Roth, MD, PhD, show how to activate only one kind of brain receptor vital for pain relief. This receptor is not involved in addiction or respiratory depression that leads to death – the most severe side...

The axon guidance cue netrin-1 and its receptor DCC promote axon branching in developing cortical neurons. In this study, we detail a novel molecular mechanism by which the brain-enriched E3 ubiquitin ligase TRIM9 orchestrates multimerization of DCC, requisite activation of FAK and Src family kinases, and increases in exocytic vesicle...

Microcephaly is a hallmark of Angelman syndrome (AS), a debilitating neurodevelopmental disorder that results from loss of function of the HECT domain E3 ubiquitin ligase, UBE3A. However, until recently, the underlying causes of slowed brain growth in individuals with AS had gone unstudied, resulting in significant gaps in understanding of...

An antenna-like structure on cells, once considered a useless vestige, appears to be important for proper brain development in mammals and when impaired can cause defects in the brain’s wiring similar to what’s seen in autism, schizophrenia, and other neuropsychiatric disorders. In lab experiments, UNC School of Medicine scientists prevented...

The Cohen Lab and NC State researchers team up to reverse TDP-43 protein aggregation, a hallmark of degenerative diseases.

In the study published July 6th in the journal Neuron titled, "Network-level Control of Frequency Tuning in Auditory Complex", Kato et al. found a neuronal network basis for how our brain precisely represents the external world.

"In a new study, Emerson et al. show that brain function in infancy can be used to accurately predict which high-risk infants will later receive an autism diagnosis...These findings must be replicated, but they represent an important step toward the early identification of individuals with autism before its characteristic symptoms...

In the journal Cancer Research, UNC Lineberger researchers led by Neuroscience Center member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify...

UNC School of Medicine research findings could lead to new drug targets for treating multiple sclerosis and other neurodegenerative diseases, including Alzheimer’s disease.

This first-of-its-kind study used MRIs to image the brains of infants, and then researchers used brain measurements and a computer algorithm to accurately predict autism before symptoms set in.