RECENT PUBLICATIONS- Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment August 7, 2024 Simon M Gray
- Mouse Adaptation of Human Inflammatory Bowel Diseases Microbiota Enhances Colonization Efficiency and Alters Microbiome Aggressiveness Depending on Recipient Colonic Inflammatory Environment February 8, 2024 Simon M Gray
- A consortia of clinical E. coli strains with distinct in vitro adherent/invasive properties establish their own co-colonization niche and shape the intestinal microbiota in inflammation-susceptible mice December 21, 2023 Rachel M Bleich
Center Features
- We provide gnotobiotic mice nationally;
- We have a highly experienced team of technical staff who perform experimental techniques;
- We provide external investigators the option for onsite tissue collection;
- We collaborate with the UNC Mutant Mouse Regional Resource Center (MMRRC) and Collaborative Cross (CC) Consortium;
- We train and support external investigators to set up their own local gnotobiotic units.
Objectives
- Provide germ-free and gnotobiotic mice to investigators across the country;
- Derive mouse strains into germ-free conditions;
- Support new investigators to generate preliminary data for grant applications;
- Train personnel to develop gnotobiotic facilities at other institutions;
- Develop and characterize complex microbial communities and libraries of bacterial strains.