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Bench to Bedside: Vascular Malformations
December 3, 2020 @ 8:00 am - 9:00 am
Julie Blatt, MD
Blatt’s interests are in pediatric solid tumors, vascular anomalies, and drug repurposing as applied to both of those areas of interest.
Blatt’s clinical interests include late effects of chemotherapy, experimental therapeutics of solid tumors, and vascular anomalies.
Blatt’s research interests fall into several areas of clinical research. The first is in Late Effects of Childhood Cancer Therapy. Past studies have focused on gonadal function, cardiotoxicity and the development of second malignancies. She has been a consultant to the Childhood Cancer Survivor Study, a multicenter NIH-funded study which is examining late effects in more than 20,000 survivors of childhood cancer. She also is a past member of the Strategy Group of the Surveillance and End Results Committee of the Children’s Oncology Group, which generates late effects study components of therapeutic trials. Current research is focused on adolescent young adult survivorship issues.
A second interest is in experimental therapeutics of childhood cancer and related diseases. Current studies involve the effects of rapamycin on solid tumors, and on drug repurposing for pediatric hematology oncology.
A newer interest is in the treatment and biology of vascular lesions including hemangiomas and vascular malformations. Her division is part of a growing multidisciplinary “clinic without walls” effort to treat these patients.
William Polachek, PhD
Dr. Polacheck’s laboratory investigates the physical interactions between cells and their environment and how forces at the cellular scale contribute to tissue development, homeostasis, and disease. To study how cells sense and generate forces in living tissue, the Polacheck lab develops microfluidic technology to build microtissues in the laboratory that mimic the architecture and multicellular function of human tissues in vivo. By integrating these organ-on-chip models with genome editing, induced-pluripotent stem cell technology, and other cell and molecular biology techniques, the Polacheck lab has developed a novel approach for understanding the molecular machinery employed by cells to generate force sand to transduce forces from their environment into biological responses. The lab seeks to leverage these biological insights to inform novel drug targets for diseases in which misregulation of cellular forces contribute to pathogenesis, such vascular disease, cancer, and fibrosis. Furthermore, the lab works to translate the technology and techniques developed to build microtissues into tissue engineered therapies for organ replacement and regenerative medicine.