Author Archives: samweiss

This new study, using data from over 2,500 participants in the AURORA, sheds light on how adverse posttraumatic neuropsychiatric sequelae (APNS) develop and change during the first two months following trauma through latent transition modeling. In this study, APNS symptoms include pain, depressive symptoms, sleep discontinuity, nightmares, somatic symptoms, concentration/thinking/fatigue,...

The North Carolina Healthy Active Living (NC HeAL) program is an innovative clinical service offered to all Coordinated Specialty Care (CSC) clients in this state. It offers personalized health and wellness coaching to help clients achieve meaningful health improvements. This paper provides a detailed description of the program’s development, the...

We present a physics-informed deep learning framework that models tau pathology propagation in Alzheimer’s disease as an optimal mass transport (OMT) problem constrained by brain geometry, enabling interpretable and accurate prediction of future PET-based pathology distribution. By learning population-level flow dynamics and forecasting subject-specific spreading trajectories, our approach offers a...

Connectivity between the networks in the brain responsible for processing visual input and coordinating response to stimuli may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of...

Connection Learning Healthcare System, one of the eight hubs of the National Institute of Mental Health funded Early Psychosis Intervention Network, supports uniform data collection, analysis, feedback and infrastructure development to promote a culture of continuous quality improvement across 25 Coordinated Specialty Care programs serving young people experiencing first episode...

Fluctuations in sex hormones may impact risk for PTSD, as estradiol has been shown to influence PTSD severity and biomarkers of PTSD. Using the AURORA data, we were able to examine how estradiol levels at the time of the trauma were associated with changes in autonomic function and fear learning...

Post-traumatic stress (PTS) symptoms and substance use behaviors commonly co-occur after a traumatic event. However, whether individual-, household-, or neigborhood-level factors impact this relationship is understudied due to lack of data on long-term outcomes and geographic variability in samples. From the Advancing Understanding of RecOvery afteR traumA (AURORA) study, we...

In the context of post-traumatic stress disorder (PTSD), there are few studies which explore how social support mitigates stress symptoms within the acute post-trauma time frame. Our study aims to explore the neural basis of social buffering in trauma recovery. Importantly, social support is a low cost and low risk...

This study explores sex differences in neural activation during response inhibition and how these differences relate to the development and progression of posttraumatic stress disorder (PTSD) after recent trauma. It found that females with lower activation in the ventromedial prefrontal cortex during inhibition were more likely to develop severe PTSD...