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Translaminar recurrence from layer 5 suppresses superficial cortical layers

June 3, 2022

The cerebral cortex is full of recurrent connectivities, and their disturbance leads to diseases such as epilepsy and schizophrenia. We found in the auditory cortex that layer 5 to layer 2/3 interlaminar recurrence provides inhibitory feedback, which may stabilize the neural activity and help appropriate information processing in the cortical circuit.