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Probing the neurocardiac circuit in trauma and posttraumatic stress

July 11, 2024

This study probed the neurocardiac circuit by examining associations among its core regions in the brain (e.g., hypothalamus) and the periphery (heart rate [HR], high frequency heart rate variability [HF-HRV], and blood pressure [BP]). Participants were 315 trauma-exposed adults enrolled from emergency departments as part of the prospective AURORA study. Among those with PTSD, lower … Read more

Polygenic risk, childhood abuse and gene x environment interactions with depression development from middle to late adulthood: A U.S. national life-course study.

July 11, 2024

Utilizing national longitudinal data, this study examined how polygenic depression risk and childhood abuse interactively influence the life-course development of depressive conditions from middle to late adulthood. The results revealed that Increasing polygenic depression scores were associated with elevated CES-D levels and potential risks of clinical depression. Non-maltreated females generally exhibited higher depressive symptoms and … Read more

A novel method for quantifying affective sensitivity to endogenous ovarian hormones

July 11, 2024

Increased sensitivity to ovarian hormone changes is implicated in the etiology of reproductive mood disorders across the female lifespan, including menstrually-related mood disorders, perinatal mood disorders, and perimenopausal depression. We developed a novel method to accurately quantify sensitivity to endogenous hormone fluctuations that may facilitate the prediction and prevention of these mental health conditions.

Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery

July 11, 2024

This work highlights the utility of prefrontomotor cross-frequency coupling as a potential motor status and recovery biomarker in stroke. The frequency- and region-specific neurocircuitry featured in this work may also facilitate novel treatment strategies in stroke.