Paige Nuebel, Author at UNC Center for Excellence in Community Mental Health

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively…read more. Kraus MS, …

Impairments in self-assessment in schizophrenia have been shown to have functional and clinical implications. Prior studies have suggested that overconfidence can be associated with poorer cognitive performance in people with schizophrenia, and that reduced awareness of performance may be associated with disability…read more. Jones MT, Deckler E, Laurrari C, Jarskog LF, Penn DL, Pinkham AE, …

Negative symptoms and depression persist in one third of patients with schizophrenia. Previous studies suggested that depression has more impact on self-perceived compared to observer-rated social functions. Reduced emotional experience, a subdomain of negative symptoms, predicts social functioning deficits, although its role in self-assessment is unclear. We examined depression and reduced emotional experience and self-reports …

Participants with schizophrenia self-reported their everyday functioning and social cognitive ability as well as their depression. All were rated with the PANSS and a separate rater generated all-sources ratings of everyday functioning and social cognitive ability. Correlations between self-reported everyday functioning and social cognitive ability, ratings of everyday functioning and social cognitive ability, and the …

Deficits in social functioning in schizophrenia are primarily predicted by negative symptoms, social cognition deficits, and social skills deficits. Here we examine those predictive variables across variations in the severity of reduced emotional experience. We hypothesized that in patients with high symptom severity, factors such as social cognition would have reduced importance for predicting social …

The effects of intranasal oxytocin, a neuropeptide involved in prosocial behavior and modulation of neural networks underlying social cognition and emotion regulation, have been studied in schizophrenia. We tested the hypothesis that twice-daily intranasal oxytocin administered for 12-weeks would improve tertiary and exploratory outcomes of self-reported social symptoms, empathy and introspective accuracy from the Jarskog …

Patients with tardive dyskinesia who completed a 12 week, phase 3, placebo-controlled trials were eligible to enter this open-label, single-arm study. The open-label study consisted of a 6 week dose-escalation phase and a long-term maintenance phase of 106 weeks. The objective was to evaluate the long-term safety and efficacy of deutetrabenazine in patients with tardive …

Schizophrenia is considered a neurodevelopmental disorder with a pathophysiology that likely begins long before the onset of clinical symptoms. White matter abnormalities have been observed in schizophrenia and we hypothesized that the first 2 years of life is a period in which white matter abnormalities associated with schizophrenia risk may emerge…read more. Ahn SJ, Cornea …

Transcranial alternating current stimulation (tACS) modulates endogenous neural oscillations in healthy human participants by the application of a low-amplitude electrical current with a periodic stimulation waveform. Yet, it is unclear if tACS can modulate and restore neural oscillations that are reduced in patients with psychiatric illnesses such as schizophrenia. Here, we asked if tACS modulates …

“What we’re doing with them comes from what they tell us they want,” VanderZwaag said. “The idea is that initially we try to help them identify what are the things they value, what are their goals for the next year and then longer term, and then we try to help them figure out what’s getting …

Come see the Institute Director share her knowledge at the conference. Keynote Presenter: Lorna Moser, PhD, HSPP, is director of the Institute for Best Practices within the University of North Carolina (UNC) Center for Excellence in Community Mental Health and is a licensed psychologist with specialized training in psychiatric rehabilitation and mental health services research. …

Author Archives: Paige Nuebel

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: psychometric properties and correlations with standard measures

Confidence, performance, and accuracy of self-assessment of social cognition: a comparison of schizophrenia patients and healthy controls

Depression and reduced emotional experience in schizophrenia: correlations with self-reported and informant rated everyday social functioning

Depression and reduced emotional experience in schizophrenia: correlations with self-reported and informant rated everyday social functioning

Autism symptoms, depression, and active social avoidance in schizophrenia: association with self-reports and informant assessments of everyday functioning

Predictors of social functioning in patients with higher and lower levels of reduced emotional experience: social cognition, social competence, and symptom severity

Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: a 12-week twice-daily randomized controlled trial

Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia

White matter development in infants at risk for schizophrenia

Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation

UNC program helps clients push through mental illness to success

Lorna Moser – Presenting at Evidence-Based Practices Conference 2016