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The reciprocal relationship between posttraumatic stress disorder symptoms and alcohol use in a large multisite longitudinal sample stratified by sex: A random-intercept cross-lagged panel model

July 22, 2025
Using a large-scale longitudinal observational emergency department (ED)-based study of individuals with recent trauma exposure, we conducted random-intercept cross-lagged panel models to test whether sex differences exist in the temporal relationships between posttraumatic stress disorder (PTSD) symptoms and alcohol use over six months (assessed at five time points timepoints: ED...

Early life adversity increases risk for chronic post-traumatic pain, data from humans and rodents

July 22, 2025
Traumatic stress exposures (TSE) are common in life. While most individuals recover following a TSE, a substantial subset develop adverse posttraumatic neuropsychiatric sequelae such as chronic posttraumatic musculoskeletal pain (CPMP). Vulnerability factors for CPMP are poorly understood, which hinders identification of high-risk individuals for targeted interventions. One known vulnerability factor...

Understanding Brain Functional Dynamics Through Neural Koopman Operator with Control Mechanism

July 22, 2025
We developed an explainable deep learning model that uses brain imaging data to uncover how cognitive states emerge from complex brain dynamics. By modeling the brain as a controllable system, our approach offers new insights into how brain function supports behavior.

Prepronociceptin-expressing neurons in the bed nucleus of the stria terminalis signal escape behavior

July 22, 2025
These results highlight a novel role of a unique set of neurons within a brain region known as the extended amygdala that signal escape behavior in response to an aversive stimulus. This, in combination with our previous findings that these same neurons encode arousal responses, supports a neurobiological relationship of...

Different Tools, Different Results: Comparing Methods for Bullying Assessment in Autistic and ADHD Youth

July 22, 2025
This study compared three tools for assessing bullying in autistic and ADHD youth and found variable patterns of prevalence and vulnerability between approaches. A disability-specific measure identified more nuanced patterns of victimization, underscoring the importance of using tailored and valid assessments in these populations.

Comparative cardiac safety of haloperidol vs. chlorpromazine among people receiving hemodialysis

July 22, 2025
Sudden cardiac death is >20 times more likely among individuals receiving maintenance hemodialysis, relative to individuals not receiving hemodialysis. We compared the comparative cardiac safety associated with typical antipsychotics among individuals receiving hemodialysis.

Electroconvulsive Therapy in a Left Ventricular Assist Device Recipient With Treatment-Resistant Depression

July 22, 2025
We present a case of a left ventricular assist devices recipient with treatment-resistant depression who was successfully treated with electroconvulsive therapy. Our case describes an approach by which electroconvulsive therapy can be safely delivered to left ventricular assist device recipients with a collaborative multidisciplinary team approach.

Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India

July 22, 2025
Our study demonstrates that training teachers in “education as mental health therapy” (Ed-MH) novel approach integrating psychological principles into everyday classroom management significantly improves children’s mental health and academic performance. The large effects we observed, similar in magnitude to medication or traditional therapy, highlight the potential of Ed-MH to bring...

Resilience and strengths in the Black autism community in the United States: A scoping review

July 22, 2025
Gaps in research knowledge pertaining to resiliency factors and strengths among the Black autism community, inclusive of autistic persons and their support system exist. A scoping review was conducted to further explore quantitative, qualitative, and mixed methods studies that investigate resiliency factors and related strengths in the Black autism community...

A Consensus Taxonomy of Altered (Nonordinary) States of Consciousness: Bringing Order to Disarray

July 22, 2025
A multi-disciplinary, international consensus of a taxonomy (classification system) for altered states of consciousness.