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Piven Earns Prestigious Lifetime Award from the International Society for Autism Research

Blue Cross NC, Carolina Across 100 and CHAAMP to partner on CARE4Youth mental health program

April Research Publications

Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure

This new study, using data from over 2,500 participants in the AURORA, sheds light on how adverse posttraumatic neuropsychiatric sequelae (APNS) develop and change during the first two months following trauma through latent transition modeling. In this study, APNS symptoms include pain, depressive symptoms, sleep discontinuity, nightmares, somatic symptoms, concentration/thinking/fatigue,...

North Carolina Healthy Active Living: Describing a Wellness Coaching Program for First-Episode Psychosis Clinics

The North Carolina Healthy Active Living (NC HeAL) program is an innovative clinical service offered to all Coordinated Specialty Care (CSC) clients in this state. It offers personalized health and wellness coaching to help clients achieve meaningful health improvements. This paper provides a detailed description of the program’s development, the...

Revealing Cortical Spreading Pathway of Neuropathological Events by Neural Optimal Mass Transport

We present a physics-informed deep learning framework that models tau pathology propagation in Alzheimerâ€™s disease as an optimal mass transport (OMT) problem constrained by brain geometry, enabling interpretable and accurate prediction of future PET-based pathology distribution. By learning population-level flow dynamics and forecasting subject-specific spreading trajectories, our approach offers a...

Functional connectivity between the visual and salience networks and autistic social features at school-age

Connectivity between the networks in the brain responsible for processing visual input and coordinating response to stimuli may play an important role in social affect symptom variability among children with ASD and those with genetic liability for ASD. These findings align with and extend earlier reports in this sample of...

Connection Learning Healthcare System Hub of the Early Psychosis Intervention Network: Program and Participant Characteristics

Connection Learning Healthcare System, one of the eight hubs of the National Institute of Mental Health funded Early Psychosis Intervention Network, supports uniform data collection, analysis, feedback and infrastructure development to promote a culture of continuous quality improvement across 25 Coordinated Specialty Care programs serving young people experiencing first episode...

Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men

Fluctuations in sex hormones may impact risk for PTSD, as estradiol has been shown to influence PTSD severity and biomarkers of PTSD. Using the AURORA data, we were able to examine how estradiol levels at the time of the trauma were associated with changes in autonomic function and fear learning...

Multi-level socioeconomic modifiers of the comorbidity of post-traumatic stress and tobacco, alcohol, and cannabis use: the importance of income

Post-traumatic stress (PTS) symptoms and substance use behaviors commonly co-occur after a traumatic event. However, whether individual-, household-, or neigborhood-level factors impact this relationship is understudied due to lack of data on long-term outcomes and geographic variability in samples. From the Advancing Understanding of RecOvery afteR traumA (AURORA) study, we...