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Patch grafting, strategies for transplantation of organoids into solid organs such as liver

December 13, 2021
Author: Yi Xianwen, PhD | Journal: Biomaterials Epithelial cell therapies have been at an impasse because of inefficient methods of transplantation to solid organs. Patch grafting strategies were established enabling transplantation of ≥107th organoids/patch of porcine GFP+ biliary tree stem/progenitors into livers of wild type hosts.

Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators

December 13, 2021
Leader Author: Robert Maile, PhD | International Journal of Molecular Sciences Severe burn injury is a devastating form of trauma that results in persistent immune dysfunction with associated morbidity and mortality. The underlying drivers of this immune dysfunction remain elusive, and there are no prognostic markers to identify at-risk patients.

Causes of death following discharge after trauma in North Carolina

December 13, 2021
Residency Author: Mary K Bryant, MD | Faculty Authors: Sharon Schiro, PhD, Lauren Raff, MD, Arielle J. Perez, MD, Trista Reid, MD | The Journal of Trauma and Acute Care Surgery While a "fourth peak" of delayed trauma mortality has been described, limited data describe the causes of death (COD)...

ACR Appropriateness Criteria® Parathyroid Adenoma

December 13, 2021
UNC Surgery Author: Lawrence Kim, MD | Journal of the American College of Radiology Hyperparathyroidism is defined as excessive parathyroid hormone production. The diagnosis is made through biochemical testing, in which imaging has no role. However, imaging is appropriate for preoperative parathyroid gland localization with the intent of surgical cure....

Radiologic Reporting of Simple Hepatic Cyst Versus Biliary Cystadenoma May Lead to Unnecessary Surgery

December 13, 2021
Authors: Aman Kumar, MD, Alex Zendel, MD, Michael Batres, MD, David A. Gerber, MD, Chirag S. Desai, MD | The American Journal of Surgery Simple liver cyst (SHC) is a benign condition with no malignant potential. They are typically discovered incidentally due to the increased use of abdominal imaging, but...

The Sociotechnical Factors Associated With Burnout in Residents in Surgical Specialties: A Qualitative Systematic Review

December 13, 2021
Surgery Authors: Ian Kratzke, MD, and Muneera Kapadia, MD, MEE | Journal of Surgical Education The consequences of burnout remain prevalent within general surgery training programs, yet there is no comprehensive description of the factors associated with burnout. Using sociotechnical systems theory, this review aims to qualitatively evaluate the factors...

Adenosine, Lidocaine, and Magnesium for Attenuating Ischemia Reperfusion Injury from Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in a Porcine Model

December 13, 2021
Lead Author: Matthew J Eckert |  Journal of Trauma and Acute Care Surgery Minimally invasive REBOA following non-compressible hemorrhage results in significant ischemia reperfusion injury (IRI). Adverse outcomes from IRI include organ dysfunction and can result in profound hemodynamic and molecular compromise. We hypothesized that ALM attenuates organ injury and inflammation...

ASTS Cellular Transplantation Committee. Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape

December 13, 2021
Lead Author: Chirag Desai, MD | American Journal of Transplantation Although cellular transplantation remains a relatively small field compared to solid organ transplantation, the prospects for advancement in basic science and clinical care remain bountiful. In this review, notable historical events and the current landscape of the field of cellular...