Structural Bioinformatics

Welcome to the R. L. Juliano Structural Bioinformatics Core facility at the University of North Carolina at Chapel Hill. The Director of this Core, Dr. Brenda Temple, is available for consultations and collaborations on research studies requiring computational structural biology methods.

One effective analysis for the identification of functionally important amino acid residues combines 3D structural analysis with molecular evolution methods, including sequence and phylogenetic studies. When experimental structures are not available, molecular modeling studies, whereby the structure of the protein of interest is predicted using known template structures, provide 3D atomic data. The analyses available through this core are not limited to the study of static structures, but also include molecular dynamics studies for analyzing the contribution of dynamic and collective motions to macromolecular functionality. All of these analyses contribute to the development of hypotheses to be tested in the laboratory, and give insight into experimental data.

For more information on what services are available go to How We Work.

To learn about available software packages go to Resources.

For examples of current research using our tools, please visit Advancing Your Research