James Yankaskas

James Yankaskas


(1969) MIT
Cambridge MA

(1972) New York U.
New York NY

(1978) U. of Connecticut School of Med
Farmington CT

Internship and Residency: 
(1978-81) Internal Medicine
U. of North Carolina
Chapel Hill NC

Clinical Fellowship: 
(1981-82) Duke U. Medical Center
Durham NC

Research Fellowship: 
(1982-84) U. of North Carolina
Chapel Hill NC

Academic Title:
Michael E. Hatcher Professor of Medicine

Office:   4007-A Thurston-Bowles Bldg.
Phone:  919-966-7054
Fax:      919-966-7524
Email:   James_Yankaskas@med.unc.edu

Research Interests:

  1. Physiology of human airway epithelia. Development and use of fresh human tissues, primary cultures and cell lines to evaluate molecular and physiological functions of airway epithelia from normal and diseased tissues.
  2. Cystic fibrosis in adults. Basic science and clinical studies of disease pathophysiology, treatment, and care measures to improve the duration and quality of life
  3. Use of systems based quality improvement methods to imrpvoe care delivery and outcomes in adult CF, pulmonary clinic, and Medical ICU's.

Recent Publications:

2000 - Present:

  1. V.J. Wheat, H. Shumaker, C. Burnham, G.E. Shull, J.R. Yankaskas, and M. Soleimani. CFTR induces the expression of DRA along with Cl /HCO3- exchange activity in tracheal epithelial cells. Am. J. Physiol. 279:C62-C71, 2000.
  2. J.R. Yankaskas and R. Aris. Outpatient care of the cystic fibrosis patient after lung transplantation. Curr. Opin. Pulm. Med. 6:551-557, 2000.
  3. L. Gao, J.R. Yankaskas, C.M. Fuller, E.J. Sorscher, S. Matalon, H.J. Forman, and C.J. Venglarik. Chlorzoxazone or 1-EBIO increases Na+ absorption across cystic fibrosis airway epithelial cells. Am. J. Physiol. 281: L1123-L1129, 2001.
  4. S.H. Randell, D.L. Walstad, U.E. Schwab, B.R. Grubb, and J.R. Yankaskas. Isolation and culture of airway epithelial cells from chronically infected human lungs. In Vitro Cell Dev Biol Anim. 2001; 37:480-489.
  5. N. Sood, L.J. Paradowski, and J.R. Yankaskas. Outcomes of intensive care unit care in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 163:335-338, 2001.
  6. A. D. Betensley, J. R. Yankaskas. Factor VIIa for alveolar hemorrhage in microscopic polyangiitis. (Letter). Am J Respir Crit Care Med 2002; 166:1291-2.
  7. J. Mungle, E. H. Burker, J. R. Yankaskas. Vocational rehabilitation counseling for adolescents and adults with cystic fibrosis. J. Applied Rehabilitation Counseling. 2002; 33:15-21.
  8. U. Schwab, M. Leigh, C. Ribeiro, J. Yankaskas, K. Burns, P. Gilligan, P. Sokol, R. Boucher. Patterns of epithelial cell invasion by different species of the Burkholderia cepacia complex in well-differentiated human airway epithelia. Infect Immun. 2002; 70:4547-55.
  9. D. Worlitzsch, R. Tarran, M. Ulrich, U. Schwab, A. Cekici, K. C. Meyer, P. Birrer, G. Bellon, J. Berger, T. Weiss, K. Botzenhart, J. R. Yankaskas, S. Randell, R. C. Boucher, G. Doring. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest. 2002; 109:317-325.
  10. J. C. Lay, M. R. Stang, P. E. Fisher, J. R. Yankaskas, W. D. Bennett. Airway retention of materials of different solubility following local intrabronchial deposition in dogs. J. Aerosol Medicine 2003: 16:153-166.
  11. M. Mall, S. M. Kreda, A. Mengos, T. J. Jensen, S. Hirtz, H. H. Seydewitz, J. Yankaskas, K. Kunzelmann, J.R. Riordan, R.C. Boucher. The F508 mutation results in loss of CFTR function and mature protein in native human colon. J. Clin Invest 2004. Gastroenterology. 2004; 126:32-41.
  12. M. Nissim-Rafinia, M. Aviram, S.H. Randell, L. Shushi, E. Ozeri, O. Chiba-Falek, O. Eidelman, H.B. Pollard, J.R. Yankaskas, B. Kerem. Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. EMBO Rep. 2004; 5:1071-1077.
  13. J. R. Yankaskas*, B. C. Marshall*, B. Sufian, R. H. Simon, and D. Rodman. Cystic Fibrosis Adult Care – Consensus Conference Report. Chest 2004; 125:1S-40S.
  14. M.L. Drumm, M.W. Konstan, M.D. Schluchter, A. Handler, R. Pace, F. Zou, M. Zariwala, D. Fargo, A. Xu, J.M. Dunn, R.J. Darrah, R. Dorfman, A.J. Sandford, M. Corey, J. Zielenski, P. Durie, K. Goddard, J.R. Yankaskas, F.A. Wright, M.R. Knowles; Gene Modifier Study Group. Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med. 2005; 353:1443-1453.
  15. S.M. Kreda, M. Mall, A. Mengos, L. Rochelle, J. Yankaskas, J.R. Riordan, R.C. Boucher. Characterization of Wild-Type and {Delta}F508 Cystic Fibrosis Transmembrane Regulator in Human Respiratory Epithelia. Mol Biol Cell. 2005; 16:2154-2167.
  16. P.A. Flume, J.R. Yankaskas, M. Ebeling, T. Hulsey, L.L. Clark. Massive hemoptysis in cystic fibrosis. Chest 2005; 128: 729-738.
  17. M.L. Fulcher, S. Gabriel, K.A. Burns, J.R. Yankaskas, S.H. Randell. Well-differentiated human airway epithelial cell cultures. Methods Mol Med. 2005; 107:183-206.
  18. M.D. Schlucter, M.K. Konstan, M.L. Drumm, J.R. Yankaskas, M.R. Knowles. Classifying severity of cystic fibrosis lung disease using longitudinal pulmonary function data. Am J Respir Crit Care Med. 2006; 174:780-786.
  19. E.P. Dellon, M.W. Leigh, J.R. Yankaskas, T.L. Noah. Effects of lung transplantation on inpatient end of life care in cystic fibrosis. J Cyst Fibros. 2007; 6:396-402.
  20. M.P. Kennedy, R.D. Coakley, S.H. Donaldson, R.M. Aris, K. Hohneker, J.P. Wedd, M.R. Knowles, P.H. Gilligan, J.R. Yankaskas. Burkholderia gladioli: Five year experience in a cystic fibrosis and lung transplantation center. J Cystic Fibrosis 2007; 6:267-273.
  21. V.A. LeGrys, J.R. Yankaskas, L.M. Quittell, B.C. Marshall, P.J. Mogayzel. Diagnostic sweat testing: the Cystic Fibrosis Foundation guidelines. J Pediatr. 2007;151:85-89.
  22. Lanken PN, Terry PB, Delisser HM, Fahy BF, Hansen-Flaschen J, Heffner JE, Levy M, Mularski RA, Osborne ML, Prendergast TJ, Rocker G, Sibbald WJ, Wilfond B, Yankaskas JR; ATS End-of-Life Care Task Force. American Thoracic Society clinical policy statement: Palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med. 2008;177:912-927.

Non-Refereed Journals and Book Chapters:

  1. R.C. Boucher, M.R. Knowles, and J.R. Yankaskas. Cystic fibrosis. In: Textbook of Respiratory Medicine, 3rd Edition, J. Murray and J. Nadel, editors. W.B. Saunders Co., Philadelphia, pp. 1291-1323, 2000.
  2. J.R. Yankaskas. Cystic fibrosis. In: Respiratory Infections, 2nd Edition, M.S. Niederman, G.A. Sarosi, and J. Glassroth, editors. Lippincott Williams & Wilkins, Philadelphia, 283-296, 2001.
  3. S. H. Donaldson and J. R. Yankaskas. Cystic Fibrosis. In: Respiratory Care Principles and Practice. D. R. Hess, N. R. MacIntyre, S. C. Mishoe, W. F. Galvin, A. B. Adams and A. B. Saposnick, editors. W. B. Saunders Company, pp 1003-1021, 2002.
  4. J. R. Yankaskas. Lung Transplantation. In: Cystic Fibrosis in Men and Women Diagnosed as Adults. Barbara Palys and Eileen Widerman, editors. Solvay Pharmaceuticals, 2003. In press.
  5. J.R. Yankaskas. Cystic Fibrosis. In: Textbook of Pulmonary Diseases. 7th Edition. J. D. Crapo, J. Glassroth, J. Karlinsky and T. King, editors. Lippincott Williams and Wilkins, Philadelphia, 247-256, 2003.
  6. J. R. Yankaskas. Bronchitis, bronchiectasis and cystic fibrosis. In: Infectious Diseases, 3nd Edition. Jonathan Cohen and William G. Powderly, editors. Mosby and Company, 359-368, 2004.
  7. J. R. Yankaskas. When CF Progresses, Transplant. In: “Now That I Have CF”, Information for Men and Women Diagnosed as Adults. Eileen Widerman, Barbara Palys and John R. Palys, editors. Solvay Pharmaceuticals, 2004.
  8. R.C. Boucher, M.R. Knowles, and J.R. Yankaskas. Cystic fibrosis. In: Textbook of Respiratory Medicine, 4th Edition, J. Murray and J. Nadel, editors. W.B. Saunders Co., Philadelphia, 1217-1251, 2005.
  9. R. Coakley and J. R. Yankaskas. Lung Transplantation for Cystic Fibrosis. In: Lung and Heart-Lung Transplantation, J. P. Lynch and D. J. Ross, editors, Lung Biology in Health and Disease series, Claude Lenfant, Executive Editor, 121-146, 2006.