Raymond Coakley, MD

Degrees

MB, BCh, BaO:
(1990) University College Dublin, National University of Ireland

Medical Residency: 
(1990-93) Royal College of Surgeons in Ireland; European Certification in Pulmonary Medicine; Fellowship in Pulmonary Medicine; Member Royal College Physicians in Ireland
(1992; 93-98; 99) Royal College of Physicians in Ireland

Fellowship:
(2000-03) U. of North Carolina at Chapel Hill

Academic Title:
Assistant Professor of Medicine

Publications:

Books and Chapters

 R Coakley, R Boucher.  Cystic Fibrosis. In Atlas of Pulmonary Medicine. 4th Edition. Editor J. Crapo Current Medicine LLC, Philadelphia, PA:  2008; pp 189-199.

R Coakley, R Boucher, Cystic Fibrosis: Pathophysiology. In Cystic Fibrosis. 3rd Edition. Editors Hodson, Geddes and Bush. Hodder Arnold London UK: 2007; pp 59-69.

R Coakley, J Yankaskas.  Lung Transplantation in Cystic Fibrosis. In Lung Biology in Health and disease Joseph Lynch Editor Marcel Dekker, New York: 2006; pp 121-147.

R Coakley, Jackson Stutts. Regulatory Functions of CFTR: In Progress in Respiratory Research: Cystic Fibrosis. A. Bush, London  (Volume Editor) and E. Alton, London; J. Davies, London; U. Griesenbach, London; A. Jaffe, London (co-editors) S. .Karger AG, Basel:  2004; pp 233-251.

R Coakley, R Boucher, S. Fiel, DV Schidlow.  Cystic Fibrosis. In Bone’s Atlas of Pulmonary Medicine. 3rd Edition. Editor J. Crapo Current Medicine LLC, Philadelphia, PA: 2004; P43 25 pages.

C Taggart, R Coakley, Glynn P, S O'Neill, NG McElvaney.  Surrogate Markers of Lung Destruction. In: LAM and other diseases of smooth muscle proliferation. Marcel Decker, New York: 1999; Page 553-571 

 Refereed papers and articles

Clunes LA, Coakley RD, Davies CM, Aleksandrov AA, Henderson AG, Zeman KL, Worthington EN, Gentzsch M, Kreda SM, Cholon D, Bennett WD, Riordan JR, Boucher RC, Tarran R. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J. 2012 26(2): 533-45.

Coakley R, Tarran R, Almond A. Fuller F, Klem E, Wolfgang M, Boucher R. Boucher R. Altered ion transport, mucus dehydration and bacterial colonization in COPD airways. Ped Pulm 2010 33: 212-4 .

Wahidi MM, Silvestri GA, Coakley R, Ferguson R, Shepherd RW et al. A prospective multi-center study of competency metrics and educational interventions in the learning of bronchoscopy among starting pulmonary fellows” CHEST. 2009 137(5):1040-9.

Coakley R, Sun H, Rasmussen JE, Chambers LA, Stackhouse JR, Okada O, Fricks I, Kendell, Harden T, Tarran R. 17beta-estradiol inhibits calcium-dependent airway surface liquid volume in cystic fibrosis airway epithelium. 2008 J Clin Invest. 2008 118(12):4025-35.

Rollins BM, Burn M, Coakley R, Chambers LA, Clunes MT, Lethem MI, Donaldson SH, Tarran R. A2B adenosine receptors regulate the mucus clearance component of the lungs innate defense system. Am J Resp Cell  Mol Biol. 2008 39(2):190-7.

Kennedy MP, Coakley R, Donaldson SD, Aris RM, Hohneker K, Wedd JP, Knowles MR, Gilligan PH, Yankaskas JR. Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation center. J Cyst Fibros. 2007 6(4): 267-73.

Yoon SS, Coakley R, Lau GW, Lymar SV, Gaston B, Karabulut AC, Hennigan RF, Hwang SH, Buettner G, Schurr MJ, Mortensen JE, Burns JL, Speert D, Boucher RC, Hassett DJ.  Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. 2006 J Clin Invest. 26; 116(2): 436-46.

Coakley R, Gray T, Hirsh A, Thornton D, Kirkham S, Koo JS, Burch L, Boucher R, Nettesheim P. Regulation of MUC5AC Mucin Secretion and Airway Surface Liquid Metabolism by IL-1b in Human Bronchial Epithelia.   Am J Physiol Lung Cell Mol Physiol 2004 286(2): L320-L330.

Coakley R, Grubb B, Paradiso A, Gatzy J, Johnson L and Boucher R. Abnormal surface liquid pH Regulation by Cultured Cystic Fibrosis Bronchial Epithelium.   Proc Nat Acad Sci USA 2003 Dec;100(26) 16083-16086.

Paradiso AM, Coakley R, Boucher RC. Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia.   J Physiol (Lond) 2003 1;548(Pt 1):203-18.

Coakley R, Taggart C, McElvaney NG and O'Neill S.  Cytosolic pH and the inflammatory microenvironment modulate cell death in human neutrophils after phagocytosis.   Blood 2002 100(9):3383-91.

Coakley R, Taggart C, Greene C, McElvaney NG and O'Neill S.  Microenvironmental pC02 regulates effector responses in human neutrophils.   J Leucoc Biol, 2002 Apr;71(4):603-10.

Coakley R and Boucher RC.  Regulation and functional significance of Airway surface liquid pH.    J Panc 2001 2(4 suppl) 274-79.

Gillie DJ, Pace AJ, Coakley R, Koller BH and Barker PM.  Liquid and ion transport by fetal airway and lung epithelia of NKCC1-deficient mice.    Am J Respir Cell Mol Biol 2001 Jul;25(1):14-20.

Coakley R. Regulation of Airway Surface Liquid pH in Cystic Fibrosis.  Ped Pulm  2001 32 (22) 120-122.

Rooney, C, Taggart C, Coakley R, McElvaney NG and O'Neill S.  C-ANCA mediated activation of human neutrophils is blocked by alpha-1 antitrypsin.   Am J Respir Cell Mol Biol  2001 Jun;24(6):747-54.

Coakley R, Taggart C, O'Neill S, McElvaney NG.  Alpha1-antitrypsin deficiency: biological answers to clinical questions.   Am J Med Sci, 2001 Jan;321(1):33-41.

Greene CM, Meachery G, Taggart CC, Rooney CP, Coakley R, O'Neill SJ, McElvaney NG.  Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis.   J Immunol 2000 Oct 15;165(8):4718-24.

Coakley R, Taggart C, Canny G, Greally P, O'Neill SJ, McElvaney NG.  Altered intracellular pH regulation in neutrophils from patients with cystic fibrosis.   Am J Physiol Lung Cell Mol Physiol  2000 Jul;279(1):L66-74.

Taggart C, Coakley R, Greally P, Canny G, O'Neill SJ, McElvaney NG.  Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8.   Am J Physiol Lung Cell Mol Physiol   2000 Jan;278(1):L33-41.

Glynn P, Coakley R, Kilgallen I, O'Neill S.  Neutrophil CD11b and soluble ICAM-1 and E-selectin in community acquired pneumonia.   Eur Respir J 1999 Jun;13(6):1380-5.

Rooney C, Taggert C, O'Neill SJ, McElvaney NG, Coakley R. Alpha 1-antitrypsin deficiency.   Ir Med J 1999 Jan-Feb 92(1):227-8.

Glynn P, Coakley R, Kilgallen I, Murphy N, O'Neill S. Circulating interleukin-6 and interleukin-10 in community acquired pneumonia.   Thorax 1999 Jan;54(1):51-5.

Keane MP, Coakley R, Costello R, O'Neill SJ.  Effect of growth hormone on human alveolar macrophage oxidative metabolism.   Thorax 1997 Sep;52(9):818-9.

Hone SW, Donnelly MJ, Robertson J, Coakley R, O'Neill S, Walsh MJ.  Dysphonia and inhalation of corticoids: a prospective study.    Rev Laryngol Otol Rhinol,   1996;117(4):331-3.