Paul Dayton

Paul Dayton

Associate Director for Education
BRIC

Associate Professor
Department of Biomedical Engineering
Eshelman School of Pharmacy

304 Taylor Hall
109 Mason Farm Road
Chapel Hill, NC 27599
919-843-9521

Dayton Lab

Education

1995 - BS in Physics, Villanova University
1998 - ME in Electrical Engineering, University of Virginia
2001 - PhD in Biomedical Engineering, University of Virginia

Research Interests
Contrast enhanced ultrasound and ultrasound mediated therapeutics. Ultrasound applications in oncology.

Research Goals

Dr. Dayton’s research involves developing new technologies for imaging blood flow, microvasculature, and molecular markers using ultrasound and microbubble contrast agents. Several of Dr. Dayton’s recent contributions to the field include techniques to improve the sensitivity and consistency of ultrasound imaging through optimization of contrast agent size distribution, the demonstration of high-resolution, high- SNR ultra broadband imaging, and techniques for real-time molecular imaging. An additional area of interest is ultrasound-mediated therapeutics with micro and nanoparticles. Dr. Dayton’s primary interest is in developing and applying tools for non-invasive assessment of angiogenesis progression and tumor response to therapy.

Publications

  1. Arena CB, Novell A, Sheeran PS, Puett C, Moyer LC, Dayton PA. (2015). Dual-frequency acoustic droplet vaporization detection for medical imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 62(9):1623-33. doi: 10.1109/TUFFC.2014.006883.
  2. Kasoji SK, Pattenden SG, Malc EP, Jayakody CN, Tsuruta JK, Mieczkowski PA, Janzen WP, Dayton PA. (2015). Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath. PLoS One, 10(7).  doi: 10.1371/journal.pone.0133014. 
  3. Kim J, Li S, Kasoji S, Dayton PA, Jiang X. (2015). Phantom evaluation of stacked-type dual-frequency 1-3 composite transducers: A feasibility study on intracavitary acoustic angiography. Ultrasonics, 63:7-15. doi: 10.1016/j.ultras.2015.06.009. 
  4. Moyer LC, Timbie KF, Sheeran PS, Price RJ, Miller GW, Dayton PA. (2015). High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. J Ther Ultrasound,3:7. doi: 10.1186/s40349-015-0029-4. 
  5. Fix SM, Borden MA, Dayton PA. (2015). Therapeutic gas delivery via microbubbles and liposomes. J Control Release, 209:139-49. doi: 10.1016/j.jconrel.2015.04.027.