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The cover art illustrates ultrasound-mediated drug delivery into a biofilm-infected wound. Illustration by Ella Marushchenko.
The cover art illustrates ultrasound-mediated drug delivery into a biofilm-infected wound. Illustration by Ella Marushchenko.

Researchers at the UNC School of Medicine and the UNC-NC State Joint Department of Biomedical Engineering, have developed a new method that combines palmitoleic acid, gentamicin, and non-invasive ultrasound to help improve drug delivery in chronic wounds that have been infected with S. aureus.

Using their new strategy, researchers including BRIC faculty member Dr. Paul Dayton, and Dr. Sarah Rowe-Conlon of the Department of Microbiology and Immunology, were able to reduce the challenging MRSA infection in the wounds of diabetic mice by 94%. They were able to completely sterilize the wounds in several of the mice, and the rest had significantly reduced bacterial burden. Their results were published in Cell Chemical Biology.

https://news.unchealthcare.org/2023/05/breaking-through-bacterial-barriers-in-chronic-treatment-resistant-wounds?utm_source=Vital+Signs&utm_campaign=Vital+Signs+5-25-23&utm_medium=email