Key words: systems biology, signal transduction, cell fate decisions, cell cycle
We study the behavior of individual cells and try to understand how groups of cells work together to carry out emergent functions. We are especially interested in “irreversible” cell fates such as apoptosis, senescence, and differentiation. How does a given cell convert molecular signals into a permanent decision? How do groups of cells balance these decisions? We use a variety of experimental and computational approaches to investigate these questions including molecular profiling, time-lapse microscopy, computational modeling, and machine learning. Our ultimate goal is to not only understand how cells make decisions under physiological conditions, but to discover how to manipulate these choices to treat disease.
- Faculty Mentoring Workshop for Biomedical Researchers
- REI Racial Equity Workshop Phase 1
Training Program Affiliations:
- Bioinformatics and Computational Biology
- Genetics and Molecular Biology